Presenilin 1 (PS1) is a key factor for beta-amyloid (Ab) formation in Alzheimer disease (AD). Homocysteine accumulation, frequently observed in AD patients, may be a sign of a metabolic alteration in the S-adenosylmethionine (SAM) cycle, which generates the overexpression of genes controlled by methylation of their promoters, when the cytosine in CpG moieties becomes unmethylated. The methylation of a gene involved in the processing of amyloid precursor protein may prevent Ab formation by silencing the gene. Here we report that SAM administration, in human neuroblastoma SK-N-SH cell cultures, downregulates PS1 gene expression and Ab production. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? / Scarpa, Sigfrido; Fuso, Andrea; D'Anselmi, Fabrizio; Rosaria A., Cavallaro. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 541:1-3(2003), pp. 145-148. [10.1016/s0014-5793(03)00277-1]

Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?

SCARPA, Sigfrido;FUSO, ANDREA;D'ANSELMI, FABRIZIO;
2003

Abstract

Presenilin 1 (PS1) is a key factor for beta-amyloid (Ab) formation in Alzheimer disease (AD). Homocysteine accumulation, frequently observed in AD patients, may be a sign of a metabolic alteration in the S-adenosylmethionine (SAM) cycle, which generates the overexpression of genes controlled by methylation of their promoters, when the cytosine in CpG moieties becomes unmethylated. The methylation of a gene involved in the processing of amyloid precursor protein may prevent Ab formation by silencing the gene. Here we report that SAM administration, in human neuroblastoma SK-N-SH cell cultures, downregulates PS1 gene expression and Ab production. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
2003
alzheimer disease; dna methylation; homocysteine; presenilin 1; s-adenosylmethionine; β-amyloid
01 Pubblicazione su rivista::01a Articolo in rivista
Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? / Scarpa, Sigfrido; Fuso, Andrea; D'Anselmi, Fabrizio; Rosaria A., Cavallaro. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 541:1-3(2003), pp. 145-148. [10.1016/s0014-5793(03)00277-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360722
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