The synthesis of bicyclo[2.2.2]octane patchouli alcohol analogues by the Sakurai conjugate addition and Nagata cyclization is described. By this approach, complementary to those so far adopted and based on the Diels-Alder addition, known analogues 2, 3 and 20 and new analogues 8-11, with 1-isopropylbicyclo[2.2.2]octane structure, could be obtained. The olfactory properties of 8 and 10 were also evaluated.
Bicyclo[2.2.2]octane Analogues of Patchouli Alcohol by Sakurai Reaction and Nagata Cyclization. Synthesis and Olfactory Properties of Novel Isopropyl Derivatives / LA BELLA, A., Popolla, I., Felici, M., Leonelli, F., Ceccacci, F., Filocamo, L., Migneco, L.M., MARINI BETTOLO, R.. - In: ARKIVOC. - ISSN 1551-7004. - ELETTRONICO. - iii:(2008), pp. 80-90.
Bicyclo[2.2.2]octane Analogues of Patchouli Alcohol by Sakurai Reaction and Nagata Cyclization. Synthesis and Olfactory Properties of Novel Isopropyl Derivatives
LA BELLA, ANGELA;LEONELLI, Francesca;CECCACCI, FRANCESCA;FILOCAMO, Luigi;MIGNECO, Luisa Maria;MARINI BETTOLO, Rinaldo
2008
Abstract
The synthesis of bicyclo[2.2.2]octane patchouli alcohol analogues by the Sakurai conjugate addition and Nagata cyclization is described. By this approach, complementary to those so far adopted and based on the Diels-Alder addition, known analogues 2, 3 and 20 and new analogues 8-11, with 1-isopropylbicyclo[2.2.2]octane structure, could be obtained. The olfactory properties of 8 and 10 were also evaluated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
