Nano-structured polymers delivering an antibiotic for the prevention of medical device-related infections were developed. Systems consisted of bovine serum albumin or polyallylamine nanoparticles alone or entrapped in a polyurethane and then loaded with cefamandole nafate, chosen as a drug model. Results showed that nanoparticles alone were able to adsorb high antibiotic amounts due to their high surface/volume ratio. However, they released cefamandole in an uncontrolled fashion, leading to a rapid loss of antibacterial activity. Improvements in the release control were obtained when CEF loaded and nonloaded nanoparticles were entrapped in a carboxylated polyurethane. For these systems the drug delivery was at least of 50% with respect to nanoparticles alone with a prolonged antimicrobial activity up to 9 days. (c) 2008 Elsevier B.V. All rights reserved.

Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles / Crisante, Fernanda; Francolini, Iolanda; Mariangela, Bellusci; Martinelli, Andrea; D'Ilario, Lucio; Piozzi, Antonella. - In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0928-0987. - STAMPA. - 36:4-5(2009), pp. 555-564. [10.1016/j.ejps.2008.12.006]

Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles

CRISANTE, Fernanda;FRANCOLINI, IOLANDA;MARTINELLI, Andrea;D'ILARIO, LUCIO;PIOZZI, Antonella
2009

Abstract

Nano-structured polymers delivering an antibiotic for the prevention of medical device-related infections were developed. Systems consisted of bovine serum albumin or polyallylamine nanoparticles alone or entrapped in a polyurethane and then loaded with cefamandole nafate, chosen as a drug model. Results showed that nanoparticles alone were able to adsorb high antibiotic amounts due to their high surface/volume ratio. However, they released cefamandole in an uncontrolled fashion, leading to a rapid loss of antibacterial activity. Improvements in the release control were obtained when CEF loaded and nonloaded nanoparticles were entrapped in a carboxylated polyurethane. For these systems the drug delivery was at least of 50% with respect to nanoparticles alone with a prolonged antimicrobial activity up to 9 days. (c) 2008 Elsevier B.V. All rights reserved.
2009
albumin; antibiotic delivery; nanoparticles; polyallylamine; polyurethanes
01 Pubblicazione su rivista::01a Articolo in rivista
Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles / Crisante, Fernanda; Francolini, Iolanda; Mariangela, Bellusci; Martinelli, Andrea; D'Ilario, Lucio; Piozzi, Antonella. - In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0928-0987. - STAMPA. - 36:4-5(2009), pp. 555-564. [10.1016/j.ejps.2008.12.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360134
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