Only 3 cases of infective endocarditis (IE) due to methicillin-resistant Staphyhlococcus haemolyticus (MRSH) have been reported in English literature. Here we report 4 cases of IE due to MRSH encountered in a single university hospital. Population analysis of the strains was performed to assess the presence of vancomycin/teicoplanin heteroresistant subpopulations. Pulsed-field gel electrophoresis was used for molecular typing of isolates. IE was defined in 3 cases as health care associated, and in 1 case, as community acquired. A causative strain was lost. Two strains were heteroresistant to teicoplanin, and 1 also to vancomycin. Genome macrorestriction profile studies demonstrated that 2 MRSH isolates belonged to clones A and E, possessing a class C1 mecDNA, whereas I clone was sporadic. All patients were treated with vancomycin plus rifampin. Two patients were cured with antibiotic therapy alone, 1 patient needed surgery, and I patient died. Methicillin-resistant multiresistant S. haemolyticus may represent a difficult-to-treat cause of both community and nosocomially acquired IE. (c) 2007 Elsevier Inc. All right reserved.

Staphylococcus haemolyticus endocarditis: clinical and microbiologic analysis of 4 cases / Falcone, Marco; Floriana, Campanile; Giannella, Maddalena; Sonia, Borbone; Stefania, Stefani; Venditti, Mario. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 57:3(2007), pp. 325-331. [10.1016/j.diagmicrobio.2006.08.019]

Staphylococcus haemolyticus endocarditis: clinical and microbiologic analysis of 4 cases

FALCONE, MARCO;GIANNELLA, MADDALENA;VENDITTI, Mario
2007

Abstract

Only 3 cases of infective endocarditis (IE) due to methicillin-resistant Staphyhlococcus haemolyticus (MRSH) have been reported in English literature. Here we report 4 cases of IE due to MRSH encountered in a single university hospital. Population analysis of the strains was performed to assess the presence of vancomycin/teicoplanin heteroresistant subpopulations. Pulsed-field gel electrophoresis was used for molecular typing of isolates. IE was defined in 3 cases as health care associated, and in 1 case, as community acquired. A causative strain was lost. Two strains were heteroresistant to teicoplanin, and 1 also to vancomycin. Genome macrorestriction profile studies demonstrated that 2 MRSH isolates belonged to clones A and E, possessing a class C1 mecDNA, whereas I clone was sporadic. All patients were treated with vancomycin plus rifampin. Two patients were cured with antibiotic therapy alone, 1 patient needed surgery, and I patient died. Methicillin-resistant multiresistant S. haemolyticus may represent a difficult-to-treat cause of both community and nosocomially acquired IE. (c) 2007 Elsevier Inc. All right reserved.
2007
heteroresistance; infective endocarditis; molecular epidemiology; staphylococcus haemolyticus; teicoplanin; vancomycin
01 Pubblicazione su rivista::01a Articolo in rivista
Staphylococcus haemolyticus endocarditis: clinical and microbiologic analysis of 4 cases / Falcone, Marco; Floriana, Campanile; Giannella, Maddalena; Sonia, Borbone; Stefania, Stefani; Venditti, Mario. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 57:3(2007), pp. 325-331. [10.1016/j.diagmicrobio.2006.08.019]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/359980
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