All types of blood cell of the body are continuously produced by rare pluripotent self-renewing HSCs (haemopoietic stem cells) by a process known as haemopoiesis. This process provides a valuable model for examining how genetic programmes involved in cell differentiation are established, and also how cell-fate specification is altered in leukaemia. Here, we describe examples of how miRNAs (microRNAs) can influence myelopoiesis and how the identification of their target mRNAs has contributed to the understanding of the molecular networks involved in the alternative control between cell growth and differentiation. Ectopic expression and knockdown of specific miRNAs have provided powerful molecular tools able to control the switch between proliferation and differentiation, therefore providing new therapeutic tools for interfering with tumorigenesis.
Role of microRNAs in myeloid differentiation / Fatica, Alessandro; Rosa, Alessandro; Ballarino, Monica; DE MARCHIS, MARIA LAURA; Rasmussen, Kd; Bozzoni, Irene. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - STAMPA. - 36:(2008), pp. 1201-1205. [10.1042/BST0361201]
Role of microRNAs in myeloid differentiation.
FATICA, Alessandro;ROSA, ALESSANDRO;BALLARINO, MONICA;DE MARCHIS, MARIA LAURA;BOZZONI, Irene
2008
Abstract
All types of blood cell of the body are continuously produced by rare pluripotent self-renewing HSCs (haemopoietic stem cells) by a process known as haemopoiesis. This process provides a valuable model for examining how genetic programmes involved in cell differentiation are established, and also how cell-fate specification is altered in leukaemia. Here, we describe examples of how miRNAs (microRNAs) can influence myelopoiesis and how the identification of their target mRNAs has contributed to the understanding of the molecular networks involved in the alternative control between cell growth and differentiation. Ectopic expression and knockdown of specific miRNAs have provided powerful molecular tools able to control the switch between proliferation and differentiation, therefore providing new therapeutic tools for interfering with tumorigenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.