The discovery of microRNAS (miRNAs) and of their mechanism of action has provided some very new clues on how gene expression is regulated. These studies established new concepts on how posttranscriptional control can fine-tune gene expression during differentiation and allowed the identification of new regulatory circuitries as well as factors involved therein. Because of the wealth of information available about the transcriptional and cellular networks involved in hematopoietic differentiation, the hematopoietic system is ideal for studying cell lineage specification. An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished.

MicroRNAs and Hematopoietic Differentiation / Fatica, Alessandro; Rosa, Alessandro; Fazi, Francesco; Ballarino, Monica; Morlando, Mariangela; De, F. G.; Caffarelli, E; Nervi, Clara; Bozzoni, Irene. - In: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. - ISSN 0091-7451. - STAMPA. - 71:(2006), pp. 205-210. [10.1101/sqb.2006.71.014]

MicroRNAs and Hematopoietic Differentiation

FATICA, Alessandro;ROSA, ALESSANDRO;FAZI, Francesco;BALLARINO, MONICA;MORLANDO, MARIANGELA;NERVI, Clara;BOZZONI, Irene
2006

Abstract

The discovery of microRNAS (miRNAs) and of their mechanism of action has provided some very new clues on how gene expression is regulated. These studies established new concepts on how posttranscriptional control can fine-tune gene expression during differentiation and allowed the identification of new regulatory circuitries as well as factors involved therein. Because of the wealth of information available about the transcriptional and cellular networks involved in hematopoietic differentiation, the hematopoietic system is ideal for studying cell lineage specification. An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished.
2006
Cell Differentiation; genetics/physiology, Gene Expression Regulation; Developmental, Hematopoiesis; genetics/physiology, Humans, Leukemia; genetics/metabolism, MicroRNAs; genetics/metabolism, Models; Biological, RNA; Neoplasm; genetics/metabolism, Transcription Factors; metabolism
01 Pubblicazione su rivista::01a Articolo in rivista
MicroRNAs and Hematopoietic Differentiation / Fatica, Alessandro; Rosa, Alessandro; Fazi, Francesco; Ballarino, Monica; Morlando, Mariangela; De, F. G.; Caffarelli, E; Nervi, Clara; Bozzoni, Irene. - In: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. - ISSN 0091-7451. - STAMPA. - 71:(2006), pp. 205-210. [10.1101/sqb.2006.71.014]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/359930
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