Aim of this study was to evaluate the effect of 5 Hz-suprathreshold repetitive transcranial magnetic stimulation (rTMS) on the duration of the spike-and-wave discharges (SWDs) in a patient presenting idiopathic absence seizures. At the moment of the study the patient presented a mild blunting of consciousness due to the high frequency of absences and EEG recordings showed sub-continuous, generalized, symmetrical and synchronous 3c/s SWDs, petit mal status. Trains of 10 stimuli (120% resting motor threshold) were delivered at 5 Hz frequency at the beginning of the SWDs. 5 Hz-rTMS trains significantly changed the EEG activity by reducing the duration of SWDs without changing the intervals between two consecutive discharges. rTMS had not significant after-effects on the epileptic activity and patient's clinical status. Despite the limitations of a single case report, our neurophysiological findings suggest that 5 Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Effects of repetitive transcranial magnetic stimulation on spike-and-wave discharges / Conte, Antonella; Francesca, Gilio; Iacovelli, Elisa; Chiara Marini, Bettolo; Carlo Di, Bonaventura; Frasca, Vittorio; Carbone, Antonio; Prencipe, Massimiliano; Berardelli, Alfredo; Inghilleri, Maurizio. - In: NEUROSCIENCE RESEARCH. - ISSN 0168-0102. - STAMPA. - 57:1(2007), pp. 140-142. [10.1016/j.neures.2006.09.015]
Effects of repetitive transcranial magnetic stimulation on spike-and-wave discharges
CONTE, ANTONELLA;IACOVELLI, ELISA;FRASCA, VITTORIO;CARBONE, Antonio;PRENCIPE, Massimiliano;BERARDELLI, Alfredo;INGHILLERI, Maurizio
2007
Abstract
Aim of this study was to evaluate the effect of 5 Hz-suprathreshold repetitive transcranial magnetic stimulation (rTMS) on the duration of the spike-and-wave discharges (SWDs) in a patient presenting idiopathic absence seizures. At the moment of the study the patient presented a mild blunting of consciousness due to the high frequency of absences and EEG recordings showed sub-continuous, generalized, symmetrical and synchronous 3c/s SWDs, petit mal status. Trains of 10 stimuli (120% resting motor threshold) were delivered at 5 Hz frequency at the beginning of the SWDs. 5 Hz-rTMS trains significantly changed the EEG activity by reducing the duration of SWDs without changing the intervals between two consecutive discharges. rTMS had not significant after-effects on the epileptic activity and patient's clinical status. Despite the limitations of a single case report, our neurophysiological findings suggest that 5 Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
