Aim of the present study was to evaluate the acute and long-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on focal epileptiform interictal EEG activity in a patient with fixation-off sensitivity and partial epilepsy. Real and sham rTMS were delivered over the vertex. Two trains of 500 stimuli per day were delivered at 0.33 Hz frequency and threshold intensity for five consecutive days. The number of posterior EEG spikes and spike-and-wave complexes/min before and after the application of rTMS were compared in a blinded manner. In our patient, real-rTMS induced a long-lasting decrease in the number of posterior EEG spikes and spike-and-wave complexes/min. Despite the limitations of a single case report, our study confirms that low-frequency rTMS significantly reduces interictal focal epileptic activity over time.

Effects of repetitive transcranial magnetic stimulation in a patient with fixation-off sensitivity / Mecarelli, Oriano; B., Gregori; F., Gilio; Conte, Antonella; Frasca, Vittorio; Accornero, Neri; Inghilleri, Maurizio. - In: EXPERIMENTAL BRAIN RESEARCH. - ISSN 0014-4819. - 173:1(2006), pp. 180-184. [10.1007/s00221-006-0577-5]

Effects of repetitive transcranial magnetic stimulation in a patient with fixation-off sensitivity

MECARELLI, Oriano;CONTE, ANTONELLA;FRASCA, VITTORIO;ACCORNERO, Neri;INGHILLERI, Maurizio
2006

Abstract

Aim of the present study was to evaluate the acute and long-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on focal epileptiform interictal EEG activity in a patient with fixation-off sensitivity and partial epilepsy. Real and sham rTMS were delivered over the vertex. Two trains of 500 stimuli per day were delivered at 0.33 Hz frequency and threshold intensity for five consecutive days. The number of posterior EEG spikes and spike-and-wave complexes/min before and after the application of rTMS were compared in a blinded manner. In our patient, real-rTMS induced a long-lasting decrease in the number of posterior EEG spikes and spike-and-wave complexes/min. Despite the limitations of a single case report, our study confirms that low-frequency rTMS significantly reduces interictal focal epileptic activity over time.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of repetitive transcranial magnetic stimulation in a patient with fixation-off sensitivity / Mecarelli, Oriano; B., Gregori; F., Gilio; Conte, Antonella; Frasca, Vittorio; Accornero, Neri; Inghilleri, Maurizio. - In: EXPERIMENTAL BRAIN RESEARCH. - ISSN 0014-4819. - 173:1(2006), pp. 180-184. [10.1007/s00221-006-0577-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/359223
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