The aim of the present study was to investigate whether basal forebrain lesions were able to impair a task requiring cognitive flexibility abilities and analyzing the effect of the rearing in an enriched environment on such form of flexibility in rats with or without basal forebrain cholinergic lesions. In adult rats reared in enriched or standard conditions of the cholinergic projection to the neocortex damage was inflicted by 192 IgG-saporin injection into Ch4 region of basal forebrain. Their performance was compared with those of intact animals reared in analogous conditions in a four-choice serial learning task which taps flexibility in adapting to changing response rules. The results underlined the crucial role of the basal forebrain in mediating cognitive flexibility behaviors and revealed that the increase in social interactions, cognitive stimulation and physical activity of the rearing in enriched environment attenuated impairments caused by the cholinergic lesion. These findi

The aim of the present study was to investigate whether basal forebrain lesions were able to impair a task requiring cognitive flexibility abilities and analyzing the effect of the rearing in an enriched environment on such form of flexibility in rats with or without basal forebrain cholinergic lesions. In adult rats reared in enriched or standard conditions of the cholinergic projection to the neocortex damage was inflicted by 192 IgG-saporin injection into Ch4 region of basal forebrain. Their performance was compared with those of intact animals reared in analogous conditions in a four-choice serial learning task which taps flexibility in adapting to changing response rules. The results underlined the crucial role of the basal forebrain in mediating cognitive flexibility behaviors and revealed that the increase in social interactions, cognitive stimulation and physical activity of the rearing in enriched environment attenuated impairments caused by the cholinergic lesion. These findings demonstrate that rearing in an enriched environment can improve the ability to cope with brain damage suffered in adulthood.

ENVIRONMENTAL ENRICHMENT MITIGATES THE EFFECTS OF BASAL FOREBRAIN LESIONS ON COGNITIVE FLEXIBILITY BEHAVIORS / P., DE BARTOLO; Leggio, Maria; L., Mandolesi; Foti, FRANCESCA IRENE; F., Gelfo; Ferlazzo, Fabio; Petrosini, Laura. - In: NEUROSCIENCE. - ISSN 0306-4522. - STAMPA. - 154:(2008), pp. 444-453. [10.1016/j.neuroscience.2008.03.069]

ENVIRONMENTAL ENRICHMENT MITIGATES THE EFFECTS OF BASAL FOREBRAIN LESIONS ON COGNITIVE FLEXIBILITY BEHAVIORS

LEGGIO, Maria;FOTI, FRANCESCA IRENE;FERLAZZO, Fabio;PETROSINI, Laura
2008

Abstract

The aim of the present study was to investigate whether basal forebrain lesions were able to impair a task requiring cognitive flexibility abilities and analyzing the effect of the rearing in an enriched environment on such form of flexibility in rats with or without basal forebrain cholinergic lesions. In adult rats reared in enriched or standard conditions of the cholinergic projection to the neocortex damage was inflicted by 192 IgG-saporin injection into Ch4 region of basal forebrain. Their performance was compared with those of intact animals reared in analogous conditions in a four-choice serial learning task which taps flexibility in adapting to changing response rules. The results underlined the crucial role of the basal forebrain in mediating cognitive flexibility behaviors and revealed that the increase in social interactions, cognitive stimulation and physical activity of the rearing in enriched environment attenuated impairments caused by the cholinergic lesion. These findi
2008
The aim of the present study was to investigate whether basal forebrain lesions were able to impair a task requiring cognitive flexibility abilities and analyzing the effect of the rearing in an enriched environment on such form of flexibility in rats with or without basal forebrain cholinergic lesions. In adult rats reared in enriched or standard conditions of the cholinergic projection to the neocortex damage was inflicted by 192 IgG-saporin injection into Ch4 region of basal forebrain. Their performance was compared with those of intact animals reared in analogous conditions in a four-choice serial learning task which taps flexibility in adapting to changing response rules. The results underlined the crucial role of the basal forebrain in mediating cognitive flexibility behaviors and revealed that the increase in social interactions, cognitive stimulation and physical activity of the rearing in enriched environment attenuated impairments caused by the cholinergic lesion. These findings demonstrate that rearing in an enriched environment can improve the ability to cope with brain damage suffered in adulthood.
192 IgG-saporin; cholinergic damage; cognitive impairment; cognitive reserve; plasticity
01 Pubblicazione su rivista::01a Articolo in rivista
ENVIRONMENTAL ENRICHMENT MITIGATES THE EFFECTS OF BASAL FOREBRAIN LESIONS ON COGNITIVE FLEXIBILITY BEHAVIORS / P., DE BARTOLO; Leggio, Maria; L., Mandolesi; Foti, FRANCESCA IRENE; F., Gelfo; Ferlazzo, Fabio; Petrosini, Laura. - In: NEUROSCIENCE. - ISSN 0306-4522. - STAMPA. - 154:(2008), pp. 444-453. [10.1016/j.neuroscience.2008.03.069]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/358972
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