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EnglishWavelength and mass resolved resonance-enhanced two photon ionization (R2PI) excitation spectra of (1S,2S)-N-Me pseudoephedrine (MPE) and its complexes with several achiral and chiral solvent mols., including water (W), Me (R)-lactate (LR), Me (S)-lactate (LS), (R)-2-butanol (BR), and (S)-2-butanol (BS), have been recorded after a supersonic mol. beam expansion and examd. in the light of ab initio calcns. The spectral patterns of the selected complexes have been interpreted in terms of the specific hydrogen-bond interactions operating in the diastereomeric complexes, whose nature in turn depends on the structure and the configuration of the solvent mol. The obtained results confirm the view that a representative neurotransmitter mol., like MPE, "communicates" with the enantiomers of a chiral substrate through different, specific interactions. These findings can be regarded as a further contribution to modeling neurotransmitter functions in biol. systems.
Modelling neurotransmitter functions: a laser spectroscopic study of (1S,2S)-N-methylpseudoephedrine and its complexes with achiral and chiral molecules / Giardini, Anna; Paladini, Alessandra; S., Piccirillo; Rondino, Flaminia; Satta, Mauro; Speranza, Maurizio. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 4(2006), pp. 2012-2018.
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| Titolo: | Modelling neurotransmitter functions: a laser spectroscopic study of (1S,2S)-N-methylpseudoephedrine and its complexes with achiral and chiral molecules |
| Autori: | |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| Citazione: | Modelling neurotransmitter functions: a laser spectroscopic study of (1S,2S)-N-methylpseudoephedrine and its complexes with achiral and chiral molecules / Giardini, Anna; Paladini, Alessandra; S., Piccirillo; Rondino, Flaminia; Satta, Mauro; Speranza, Maurizio. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - STAMPA. - 4(2006), pp. 2012-2018. |
| Handle: | http://hdl.handle.net/11573/358618 |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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