Extracellular signal-regulated kinase1/2 (ERK1/2) is frequently found constitutively activated (p-ERK1/2) in hematopoietic diseases, suggesting a role in leukernogenesis. The aim of this study was to assess the expression and clinical role of p-ERK1/2 in adult acute lymphoblastic leukemia (ALL). In 131 primary samples from adult de novo ALL patients enrolled in the Gruppo Italiano per le Malattle Ematologiche dell'Adulto (GIMEMA) Leucemia Acute Linfoide (LAL) 2000 protocol and evaluated by flow cytometry, constitutive ERK1/2 activation was found in 34.5% of cases; these results were significantly associated with higher white blood cell (WBC) values (P =.013). In a multivariate analysis, p-ERK1/2 expression was an independent predictor of complete remission achievement (P =.027). Effective approaches toward MEK inhibition need to be explored in order to evaluate whether this may represent a new therapeutic strategy for adult ALL patients.
ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia / C., Gregorj; Ricciardi, Maria Rosaria; M. T., Petrucci; M. C., Scerpa; F., De Cave; P., Fazi; Vignetti, Marco; A., Vitale; M., Mancini; Cimino, Giuseppe; S., Palmieri; F., Di Raimondo; G., Specchia; F., Fabbiano; N., Cantore; F., Mosna; A., Camera; M., Luppi; L., Annino; E., Miraglia; G., Fioritoni; F., Ronco; Meloni, Giovanna; Mandelli, Franco; M., Andreeff; M., Milella; Foa, Roberto; Tafuri, Agostino. - In: BLOOD. - ISSN 0006-4971. - 109:12(2007), pp. 5473-5476. [10.1182/blood-2006-05-021071]
ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
RICCIARDI, Maria Rosaria;VIGNETTI, Marco;CIMINO, Giuseppe;MELONI, Giovanna;MANDELLI, Franco;FOA, Roberto;TAFURI, Agostino
2007
Abstract
Extracellular signal-regulated kinase1/2 (ERK1/2) is frequently found constitutively activated (p-ERK1/2) in hematopoietic diseases, suggesting a role in leukernogenesis. The aim of this study was to assess the expression and clinical role of p-ERK1/2 in adult acute lymphoblastic leukemia (ALL). In 131 primary samples from adult de novo ALL patients enrolled in the Gruppo Italiano per le Malattle Ematologiche dell'Adulto (GIMEMA) Leucemia Acute Linfoide (LAL) 2000 protocol and evaluated by flow cytometry, constitutive ERK1/2 activation was found in 34.5% of cases; these results were significantly associated with higher white blood cell (WBC) values (P =.013). In a multivariate analysis, p-ERK1/2 expression was an independent predictor of complete remission achievement (P =.027). Effective approaches toward MEK inhibition need to be explored in order to evaluate whether this may represent a new therapeutic strategy for adult ALL patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
