Plant growth and development are sustained by meristems. Meristem activity is controlled by auxin and cytokinin, two hormones whose interactions in determining a specific developmental output are still poorly understood. By means of a comprehensive genetic and molecular analysis in Arabidopsis, we show that a primary cytokinin-response transcription factor, ARR1, activates the gene SHY2/IAA3 (SHY2), a repressor of auxin signaling that negatively regulates the PIN auxin transport facilitator genes: thereby, cytokinin causes auxin redistribution, prompting cell differentiation. Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root growth is the result of the interaction between cytokinin and auxin through a simple regulatory circuit converging on the SHY2 gene.

A genetic framework for the control of cell division and differentiation in the root meristem / DELLO IOIO, Raffaele; K., Nakamura; Moubayidin, Laila; Perilli, Serena; M., Taniguchi; M. T., Morita; T., Aoyama; Costantino, Paolo; Sabatini, Sabrina. - In: SCIENCE. - ISSN 0036-8075. - 322:5906(2008), pp. 1380-1384. [10.1126/science.1164147]

A genetic framework for the control of cell division and differentiation in the root meristem

DELLO IOIO, RAFFAELE;MOUBAYIDIN, LAILA;PERILLI, SERENA;COSTANTINO, Paolo;SABATINI, Sabrina
2008

Abstract

Plant growth and development are sustained by meristems. Meristem activity is controlled by auxin and cytokinin, two hormones whose interactions in determining a specific developmental output are still poorly understood. By means of a comprehensive genetic and molecular analysis in Arabidopsis, we show that a primary cytokinin-response transcription factor, ARR1, activates the gene SHY2/IAA3 (SHY2), a repressor of auxin signaling that negatively regulates the PIN auxin transport facilitator genes: thereby, cytokinin causes auxin redistribution, prompting cell differentiation. Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root growth is the result of the interaction between cytokinin and auxin through a simple regulatory circuit converging on the SHY2 gene.
2008
01 Pubblicazione su rivista::01a Articolo in rivista
A genetic framework for the control of cell division and differentiation in the root meristem / DELLO IOIO, Raffaele; K., Nakamura; Moubayidin, Laila; Perilli, Serena; M., Taniguchi; M. T., Morita; T., Aoyama; Costantino, Paolo; Sabatini, Sabrina. - In: SCIENCE. - ISSN 0036-8075. - 322:5906(2008), pp. 1380-1384. [10.1126/science.1164147]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/358413
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