Viruses adhering to the sperm surface are described in the semen of HIV-1-infected individuals, although viral adhesion mechanisms have yet to be fully understood. We demonstrate, by cytometric analysis and immunofluorescence microscopy, the presence of beta-chemokine receptor 5 (CCR5) on the periacrosomal region of ejaculated spermatozoa. CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection.
HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa / Barbara, Muciaccia; Padula, Fabrizio; Gandini, Loredana; Lenzi, Andrea; Stefanini, Mario. - In: AIDS. - ISSN 0269-9370. - 19:13(2005), pp. 1424-1426. [10.1097/01.aids.0000180809.04427.04]
HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa
PADULA, Fabrizio;GANDINI, Loredana;LENZI, Andrea;STEFANINI, Mario
2005
Abstract
Viruses adhering to the sperm surface are described in the semen of HIV-1-infected individuals, although viral adhesion mechanisms have yet to be fully understood. We demonstrate, by cytometric analysis and immunofluorescence microscopy, the presence of beta-chemokine receptor 5 (CCR5) on the periacrosomal region of ejaculated spermatozoa. CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
