Viruses adhering to the sperm surface are described in the semen of HIV-1-infected individuals, although viral adhesion mechanisms have yet to be fully understood. We demonstrate, by cytometric analysis and immunofluorescence microscopy, the presence of beta-chemokine receptor 5 (CCR5) on the periacrosomal region of ejaculated spermatozoa. CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection.

HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa / Barbara, Muciaccia; Padula, Fabrizio; Gandini, Loredana; Lenzi, Andrea; Stefanini, Mario. - In: AIDS. - ISSN 0269-9370. - 19:13(2005), pp. 1424-1426. [10.1097/01.aids.0000180809.04427.04]

HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa

PADULA, Fabrizio;GANDINI, Loredana;LENZI, Andrea;STEFANINI, Mario
2005

Abstract

Viruses adhering to the sperm surface are described in the semen of HIV-1-infected individuals, although viral adhesion mechanisms have yet to be fully understood. We demonstrate, by cytometric analysis and immunofluorescence microscopy, the presence of beta-chemokine receptor 5 (CCR5) on the periacrosomal region of ejaculated spermatozoa. CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection.
2005
01 Pubblicazione su rivista::01a Articolo in rivista
HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa / Barbara, Muciaccia; Padula, Fabrizio; Gandini, Loredana; Lenzi, Andrea; Stefanini, Mario. - In: AIDS. - ISSN 0269-9370. - 19:13(2005), pp. 1424-1426. [10.1097/01.aids.0000180809.04427.04]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/358246
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