Fertility is usually restored in women after solid organ transplantation, and successful pregnancies have been reported in female recipients of kidney, liver, heart, pancreas-liver, and lung transplants. However, women with solid organ allografts have higher incidence of pregnancy complications like hypertension, preeclampsia, preterm delivery. Hypertension appears to be dependent on the type of immunosuppressive agents. The influence of pregnancy on the risk of rejection is poorly known on the basis of available data. Rejection rate appears to be at least similar to the nonpregnant population. In some cases, such as in liver transplant pregnant women, even higher as compared to the nonpregnant population. Maintaining appropriate blood levels of immunosuppressive drugs is currently recommended. Malformation rate in the offsprings of transplanted women appears to not be increased; long-term follow-up of children born to allograft recipients is necessary to investigate possible developmental, immunological, or oncological disorders. We followed 70 pregnancies after kidney transplantation and nine after liver transplantation. All recipients were maintained on immunosuppressive therapy during pregnancy, except one mother who refused immunosuppression and experienced transplant rejection. Hypertension was the most frequent complication during pregnancy: in 23% of kidney transplantated mothers and in one out of nine liver transplant recipients. The only malformation observed in the newborns was the dislocation of the hip in the child of a kidney transplant recipient.

Fertility following solid organ transplantation / FRAMARINO DEI MALATESTA, Marialuisa; Rossi, Massimo; Rocca, Bianca Cristina; Iappelli, Massimo; Poli, Luca; Piccioni, Maria Grazia; T., Gentile; L., Landucci; Berloco, Pasquale Bartolomeo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 39:6(2007), pp. 2001-2004. (Intervento presentato al convegno 30th Congress of the Italian-Society-of-Organ-Transplantation tenutosi a Padova, ITALY nel NOV 30-DEC 02, 2006) [10.1016/j.transproceed.2007.05.014].

Fertility following solid organ transplantation

FRAMARINO DEI MALATESTA, Marialuisa;ROSSI, MASSIMO;ROCCA, Bianca Cristina;IAPPELLI, Massimo;POLI, Luca;PICCIONI, Maria Grazia;BERLOCO, Pasquale Bartolomeo
2007

Abstract

Fertility is usually restored in women after solid organ transplantation, and successful pregnancies have been reported in female recipients of kidney, liver, heart, pancreas-liver, and lung transplants. However, women with solid organ allografts have higher incidence of pregnancy complications like hypertension, preeclampsia, preterm delivery. Hypertension appears to be dependent on the type of immunosuppressive agents. The influence of pregnancy on the risk of rejection is poorly known on the basis of available data. Rejection rate appears to be at least similar to the nonpregnant population. In some cases, such as in liver transplant pregnant women, even higher as compared to the nonpregnant population. Maintaining appropriate blood levels of immunosuppressive drugs is currently recommended. Malformation rate in the offsprings of transplanted women appears to not be increased; long-term follow-up of children born to allograft recipients is necessary to investigate possible developmental, immunological, or oncological disorders. We followed 70 pregnancies after kidney transplantation and nine after liver transplantation. All recipients were maintained on immunosuppressive therapy during pregnancy, except one mother who refused immunosuppression and experienced transplant rejection. Hypertension was the most frequent complication during pregnancy: in 23% of kidney transplantated mothers and in one out of nine liver transplant recipients. The only malformation observed in the newborns was the dislocation of the hip in the child of a kidney transplant recipient.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Fertility following solid organ transplantation / FRAMARINO DEI MALATESTA, Marialuisa; Rossi, Massimo; Rocca, Bianca Cristina; Iappelli, Massimo; Poli, Luca; Piccioni, Maria Grazia; T., Gentile; L., Landucci; Berloco, Pasquale Bartolomeo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 39:6(2007), pp. 2001-2004. (Intervento presentato al convegno 30th Congress of the Italian-Society-of-Organ-Transplantation tenutosi a Padova, ITALY nel NOV 30-DEC 02, 2006) [10.1016/j.transproceed.2007.05.014].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/358075
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