Four new perylene derivatives with three and four basic side-chains are reported here as G-quadruplex interactive compounds. The new perylene derivatives are readily soluble in water and not self-aggregated, in contrast to what happens with the previously reported two side-chain perylene derivatives. All four compounds are able to induce the G-quadruplex and to inhibit 50% of telomerase activity at about 5 μM concentration, showing a similar efficiency with respect to each other. Molecular modelling studies are presented to try to explain these findings. © 2007 Elsevier Ltd. All rights reserved.
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|Titolo:||New highly hydrosoluble and not self-aggregated perylene derivatives with three and four polar side-chains as G-quadruplex telomere targeting agents and telomerase inhibitors|
|Data di pubblicazione:||2007|
|Appartiene alla tipologia:||01a Articolo in rivista|