The basic molecular mechanisms regulating prostate cancer (PCA) development and progression are very poorly understood. Different tumor suppressor genes are implicated in PCA. In particular, since the mutation rate of the p53 gene is also low, researchers have speculated that an infectious agent might play an important role in PCA. Polyomaviruses are candidates for this agent. We selected a patient with a diagnosis of PCA and underwent radical prostatectomy, to investigate the presence of polyomavirus BK (BKV) sequences (urine and neoplastic tissues) and the mutation pattern of p53 gene. The results obtained showed the presence of BKV DNA and of p53 gene mutations in exons 6, 8 and 9. We speculate that BKV might contribute to cellular transformation process, triggered possibly by p53 gene mutations.

A case of human polyomavirus bk infection in a patient affected by late stage prostate cancer: Could viral infection be correlated with cancer progression? / Fioriti, Daniela; G., Russo; Mischitelli, Monica; Anzivino, Elena; Bellizzi, Anna; F., Di Monaco; DI SILVERIO, Franco; A., Giordano; Chiarini, Fernanda; Pietropaolo, Valeria Antonietta. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 20:2(2007), pp. 405-411.

A case of human polyomavirus bk infection in a patient affected by late stage prostate cancer: Could viral infection be correlated with cancer progression?

FIORITI, DANIELA;MISCHITELLI, MONICA;ANZIVINO, ELENA;BELLIZZI, ANNA;DI SILVERIO, Franco;CHIARINI, Fernanda;PIETROPAOLO, Valeria Antonietta
2007

Abstract

The basic molecular mechanisms regulating prostate cancer (PCA) development and progression are very poorly understood. Different tumor suppressor genes are implicated in PCA. In particular, since the mutation rate of the p53 gene is also low, researchers have speculated that an infectious agent might play an important role in PCA. Polyomaviruses are candidates for this agent. We selected a patient with a diagnosis of PCA and underwent radical prostatectomy, to investigate the presence of polyomavirus BK (BKV) sequences (urine and neoplastic tissues) and the mutation pattern of p53 gene. The results obtained showed the presence of BKV DNA and of p53 gene mutations in exons 6, 8 and 9. We speculate that BKV might contribute to cellular transformation process, triggered possibly by p53 gene mutations.
bk virus; human polyomavirus bk; p53 gene; p53 gene mutations; polymerase chain reaction; prostate cancer; quantitative polymerase chain reaction
01 Pubblicazione su rivista::01a Articolo in rivista
A case of human polyomavirus bk infection in a patient affected by late stage prostate cancer: Could viral infection be correlated with cancer progression? / Fioriti, Daniela; G., Russo; Mischitelli, Monica; Anzivino, Elena; Bellizzi, Anna; F., Di Monaco; DI SILVERIO, Franco; A., Giordano; Chiarini, Fernanda; Pietropaolo, Valeria Antonietta. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 20:2(2007), pp. 405-411.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/357716
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