Beta2-glycoprotein I (beta 2-GPI), an abundant 50 kDa plasma glycoprotein, is the most common target for antiphospholipid antibodies (aPLs). These autoantibodies are associated with thrombotic events in patients with anti-phospholipid antibody syndrome (APS) and systemic lupus erythematosus (SLE) and are proatherogenic. beta 2-GPI can also stimulate a vigorous adaptive cellular immune response in these patients. Although much is known about beta 2-GPI as a cofactor in autoimmune diseases, crucial information is still lacking to clarify why this abundant self plasma protein is the target of autoimmune responses. Throughout the years, a remarkable number of theories have been proposed to explain how the immune system recognises self. On the basis of a large variety of epidemiological, clinical and experimental evidence, it has been suggested that an unfortunate interplay of genetic susceptibility and environmental factors may play an important role in generating an abnormal immune response. Among the environmental factors, oxidative stress is one of the major events causing protein structural modifications, thus inducing the appearance of neo/cryptic epitopes of beta 2-GPI able to activate the immune system. In particular, oxidized beta 2-GPI is able to induce phenotypic and functional maturation of dendritic cells which represent the link between innate and adaptive immunity. Chronic activation of autoimmune reactions against this self protein modified by oxidative events may contribute to local and systemic inflammation, thus sustaining endothelial dysfunction in patients with APS, SLE and cardiovascular diseases. The role of oxidative stress in beta 2-GPI-mediated immune response is described in the light of our research experience and of relevant literature emerging in the field.

Oxidized Human Beta2-Glycoprotein I: Its Impact on Innate Immune Cells / B., Buttari; E., Profumo; A., Capozzi; Sorice, Maurizio; R., Rigano. - In: CURRENT MOLECULAR MEDICINE. - ISSN 1566-5240. - STAMPA. - 11:9(2011), pp. 719-725. [10.2174/156652411798062377]

Oxidized Human Beta2-Glycoprotein I: Its Impact on Innate Immune Cells

A. Capozzi;SORICE, Maurizio;
2011

Abstract

Beta2-glycoprotein I (beta 2-GPI), an abundant 50 kDa plasma glycoprotein, is the most common target for antiphospholipid antibodies (aPLs). These autoantibodies are associated with thrombotic events in patients with anti-phospholipid antibody syndrome (APS) and systemic lupus erythematosus (SLE) and are proatherogenic. beta 2-GPI can also stimulate a vigorous adaptive cellular immune response in these patients. Although much is known about beta 2-GPI as a cofactor in autoimmune diseases, crucial information is still lacking to clarify why this abundant self plasma protein is the target of autoimmune responses. Throughout the years, a remarkable number of theories have been proposed to explain how the immune system recognises self. On the basis of a large variety of epidemiological, clinical and experimental evidence, it has been suggested that an unfortunate interplay of genetic susceptibility and environmental factors may play an important role in generating an abnormal immune response. Among the environmental factors, oxidative stress is one of the major events causing protein structural modifications, thus inducing the appearance of neo/cryptic epitopes of beta 2-GPI able to activate the immune system. In particular, oxidized beta 2-GPI is able to induce phenotypic and functional maturation of dendritic cells which represent the link between innate and adaptive immunity. Chronic activation of autoimmune reactions against this self protein modified by oxidative events may contribute to local and systemic inflammation, thus sustaining endothelial dysfunction in patients with APS, SLE and cardiovascular diseases. The role of oxidative stress in beta 2-GPI-mediated immune response is described in the light of our research experience and of relevant literature emerging in the field.
2011
autoimmunity; beta2-glycoprotein i; dendritic cells; endothelial dysfunction; innate immunity; monocytes; oxidative stress
01 Pubblicazione su rivista::01a Articolo in rivista
Oxidized Human Beta2-Glycoprotein I: Its Impact on Innate Immune Cells / B., Buttari; E., Profumo; A., Capozzi; Sorice, Maurizio; R., Rigano. - In: CURRENT MOLECULAR MEDICINE. - ISSN 1566-5240. - STAMPA. - 11:9(2011), pp. 719-725. [10.2174/156652411798062377]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/357482
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