BACKGROUND About 43% of men with low Gleason grade prostate cancer (PCa) at biopsy will be finally diagnosed with high-grade PCa at radical prostatectomy (RP). Gleason sum at RP is a good indicator of biochemical recurrence and poor clinical outcome. Therefore, there is a need to improve clinical evaluation of PCa aggressiveness in order to choice appropriate treatment. To this aim an easy-available tool is represented by circulating biomarkers. Among these, the best candidates are some molecules involved in PCa pathogenesis such as IGFBP-2 and IGFBP-3, IL-6, and its soluble receptor (SIL-6R). METHODS. In this study, we evaluated the ability of preoperative IGFBP-2, IGFBP-3, IL-6, and SIL-6R serum levels to predict Gleason score upgrade in 52 PCa patients. RESULTS. We found that IGFBP-3 median levels were significantly lower in patients who showed Gleason upgrading from biopsy to RP (P = 0.024). We also found an association between biopsy T-stage and Gleason Upgrade (P = 0.011). Using multivariate logistic regression model, we demonstrated that the association of IGFBP-3 serum levels together with biopsy T-stage and biopsy Gleason score was useful to calculate a prognostic risk score. ROC curve analysis of risk score showed a good ability to predict GSU (AUC 0.81; 95% CI 0.69-0.93). CONCLUSIONS. Our results suggest that preoperative IGFBP-3 circulating levels determination may be useful to predict Gleason score upgrading alone and/ or in combination with biopsy T-stage and biopsy Gleason score. Prostate 72: 100-107, 2012. (C) 2011 Wiley Periodicals, Inc.

Preoperative insulin-like growth factor-binding protein-3 (IGFBP-3) blood level predicts gleason sum upgrading / Daniela, Terracciano; Dario, Bruzzese; Matteo, Ferro; Claudia, Mazzarella; Giuseppe Di, Lorenzo; Vincenzo, Altieri; Angela, Mariano; Vincenzo, Macchia; DI CARLO, Angelina. - In: THE PROSTATE. - ISSN 0270-4137. - 72:1(2012), pp. 100-107. [10.1002/pros.21411]

Preoperative insulin-like growth factor-binding protein-3 (IGFBP-3) blood level predicts gleason sum upgrading

DI CARLO, ANGELINA
2012

Abstract

BACKGROUND About 43% of men with low Gleason grade prostate cancer (PCa) at biopsy will be finally diagnosed with high-grade PCa at radical prostatectomy (RP). Gleason sum at RP is a good indicator of biochemical recurrence and poor clinical outcome. Therefore, there is a need to improve clinical evaluation of PCa aggressiveness in order to choice appropriate treatment. To this aim an easy-available tool is represented by circulating biomarkers. Among these, the best candidates are some molecules involved in PCa pathogenesis such as IGFBP-2 and IGFBP-3, IL-6, and its soluble receptor (SIL-6R). METHODS. In this study, we evaluated the ability of preoperative IGFBP-2, IGFBP-3, IL-6, and SIL-6R serum levels to predict Gleason score upgrade in 52 PCa patients. RESULTS. We found that IGFBP-3 median levels were significantly lower in patients who showed Gleason upgrading from biopsy to RP (P = 0.024). We also found an association between biopsy T-stage and Gleason Upgrade (P = 0.011). Using multivariate logistic regression model, we demonstrated that the association of IGFBP-3 serum levels together with biopsy T-stage and biopsy Gleason score was useful to calculate a prognostic risk score. ROC curve analysis of risk score showed a good ability to predict GSU (AUC 0.81; 95% CI 0.69-0.93). CONCLUSIONS. Our results suggest that preoperative IGFBP-3 circulating levels determination may be useful to predict Gleason score upgrading alone and/ or in combination with biopsy T-stage and biopsy Gleason score. Prostate 72: 100-107, 2012. (C) 2011 Wiley Periodicals, Inc.
2012
il-6; gleason upgrading; igfbp-2; psa; sil-6r; igfbp-3
01 Pubblicazione su rivista::01a Articolo in rivista
Preoperative insulin-like growth factor-binding protein-3 (IGFBP-3) blood level predicts gleason sum upgrading / Daniela, Terracciano; Dario, Bruzzese; Matteo, Ferro; Claudia, Mazzarella; Giuseppe Di, Lorenzo; Vincenzo, Altieri; Angela, Mariano; Vincenzo, Macchia; DI CARLO, Angelina. - In: THE PROSTATE. - ISSN 0270-4137. - 72:1(2012), pp. 100-107. [10.1002/pros.21411]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/356981
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