We report two reactions of RNA G:C sequences occurring nonenzymatically in water in the absence of any added cofactor or metal ion: (a) sequence complementarity-driven terminal ligation and (b) complemental), sequence adaptor-driven multiple tandemization. The two abiotic reactions increase the chemical complexity of the resulting pool of RNA molecules and change the Shannon information of the initial population of sequences.
Sequence Complementarity-Driven Nonenzymatic Ligation of RNA / Pino, Samanta; Giovanna Maria, Costanzo; Giorgi, Alessandra; DI MAURO, Ernesto. - In: BIOCHEMISTRY. - ISSN 0006-2960. - STAMPA. - 50:14(2011), pp. 2994-3003. [10.1021/bi101981z]
Sequence Complementarity-Driven Nonenzymatic Ligation of RNA
PINO, SAMANTA;GIORGI, ALESSANDRA;DI MAURO, Ernesto
2011
Abstract
We report two reactions of RNA G:C sequences occurring nonenzymatically in water in the absence of any added cofactor or metal ion: (a) sequence complementarity-driven terminal ligation and (b) complemental), sequence adaptor-driven multiple tandemization. The two abiotic reactions increase the chemical complexity of the resulting pool of RNA molecules and change the Shannon information of the initial population of sequences.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
