The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction - hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction - all argue for a unitary account of drug addiction. This view is challenged by behavioural, cognitive and neurobiological findings in laboratory animals and humans. Here, we argue that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.

Opiate versus psychostimulant addiction: the differences do matter / Badiani, Aldo; David, Belin; David, Epstein; Donna, Calu; Yavin, Shaham. - In: NATURE REVIEWS. NEUROSCIENCE. - ISSN 1471-003X. - STAMPA. - 12:11(2011), pp. 685-700. [10.1038/nrn3104]

Opiate versus psychostimulant addiction: the differences do matter

BADIANI, Aldo;
2011

Abstract

The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction - hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction - all argue for a unitary account of drug addiction. This view is challenged by behavioural, cognitive and neurobiological findings in laboratory animals and humans. Here, we argue that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
2011
psychostimulants; cocaine; opioids; opiates; addiction; drug addiction; drug dependence; heroin
01 Pubblicazione su rivista::01a Articolo in rivista
Opiate versus psychostimulant addiction: the differences do matter / Badiani, Aldo; David, Belin; David, Epstein; Donna, Calu; Yavin, Shaham. - In: NATURE REVIEWS. NEUROSCIENCE. - ISSN 1471-003X. - STAMPA. - 12:11(2011), pp. 685-700. [10.1038/nrn3104]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/356299
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