The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequencies of 14 KCNAB1 intronic SNPs were determined in 142 Italian LTE patients and 104 healthy controls and statistically evaluated. Single SNP analysis revealed one SNP (rs992353) located near the 3'end of KCNAB1 slightly associated with LTE after multiple testing correction (odds ratio = 2.25; 95% confidence interval 1.26-4.04; P=0.0058). Haplotype analysis revealed two haplotypes with frequencies higher in cases than in controls, and these differences were statistically significant after permutation tests (Psim = 0.047 and 0.034). One of these haplotypes was shown to confer a high risk for the syndrome (odds ratio = 12.24; 95% confidence interval 1.32-113.05) by logistic regression analysis. These results support KCNAB1 as a susceptibility gene for LTE, in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy. (C) 2011 Elsevier B.V. All rights reserved.

Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy / Giorgia, Busolin; Sandro, Malacrida; Francesca, Bisulli; Pasquale, Striano; Carlo Di, Bonaventura; Gabriella, Egeo; Elena, Pasini; Vittoria, Cianci; Edoardo, Ferlazzo; Amedeo, Bianchi; Giangennaro, Coppola; Maurizio, Elia; Mecarelli, Oriano; Giuseppe, Gobbi; Susanna, Casellato; Marco, Marchini; Simona, Binelli; Elena, Freri; Tiziana, Granata; Annio, Posar; Antonia, Parmeggiani; Piernanda, Vigliano; Clementina, Boniver; Umberto, Aguglia; Salvatore, Striano; Paolo, Tinuper; Giallonardo, Anna Teresa; Roberto, Michelucci; Carlo, Nobile. - In: EPILEPSY RESEARCH. - ISSN 0920-1211. - 94:1-2(2011), pp. 110-116. [10.1016/j.eplepsyres.2011.01.010]

Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy

MECARELLI, Oriano;GIALLONARDO, Anna Teresa;
2011

Abstract

The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequencies of 14 KCNAB1 intronic SNPs were determined in 142 Italian LTE patients and 104 healthy controls and statistically evaluated. Single SNP analysis revealed one SNP (rs992353) located near the 3'end of KCNAB1 slightly associated with LTE after multiple testing correction (odds ratio = 2.25; 95% confidence interval 1.26-4.04; P=0.0058). Haplotype analysis revealed two haplotypes with frequencies higher in cases than in controls, and these differences were statistically significant after permutation tests (Psim = 0.047 and 0.034). One of these haplotypes was shown to confer a high risk for the syndrome (odds ratio = 12.24; 95% confidence interval 1.32-113.05) by logistic regression analysis. These results support KCNAB1 as a susceptibility gene for LTE, in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy. (C) 2011 Elsevier B.V. All rights reserved.
lateral temporal epilepsy; kcnab1; snps; case-control study; haplotype analysis
01 Pubblicazione su rivista::01a Articolo in rivista
Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy / Giorgia, Busolin; Sandro, Malacrida; Francesca, Bisulli; Pasquale, Striano; Carlo Di, Bonaventura; Gabriella, Egeo; Elena, Pasini; Vittoria, Cianci; Edoardo, Ferlazzo; Amedeo, Bianchi; Giangennaro, Coppola; Maurizio, Elia; Mecarelli, Oriano; Giuseppe, Gobbi; Susanna, Casellato; Marco, Marchini; Simona, Binelli; Elena, Freri; Tiziana, Granata; Annio, Posar; Antonia, Parmeggiani; Piernanda, Vigliano; Clementina, Boniver; Umberto, Aguglia; Salvatore, Striano; Paolo, Tinuper; Giallonardo, Anna Teresa; Roberto, Michelucci; Carlo, Nobile. - In: EPILEPSY RESEARCH. - ISSN 0920-1211. - 94:1-2(2011), pp. 110-116. [10.1016/j.eplepsyres.2011.01.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/355476
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