Aim of the study was to correlate the clinical outcome of eighteen patients who have undergone an allogeneic stem cell transplant (SCT) with the concentration in the peripheral blood (PB) of lymphocyte subpopulations evaluated at 1 year from transplant. The occurrence of acute GVHD and CMV infection correlated with the concentration of Tregs in the PB; CMV infection also correlated with the content of NK cells. The obtained results document that the concentration of Tregs in the PB after an allogeneic SCT may protect from GVHD and from CMV infection; the potential anti-viral role of NK cells is confirmed. © 2011 Elsevier Ltd.
The immune reconstitution after an allogeneic stem cell transplant correlates with the risk of graft-versus-host disease and cytomegalovirus infection / Giovanni F., Torelli; Barbarella, Lucarelli; Anna P., Iori; Maria S., De Propris; Angela, Capobianchi; Walter, Barberi; Veronica, Valle; Emilia, Iannella; Fiammetta, Natalino; Caterina, Mercanti; Salvatore, Perrone; Gentile, Giuseppe; Guarini, Anna; Foa, Roberto. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - ELETTRONICO. - 35:8(2011), pp. 1124-1126. [10.1016/j.leukres.2011.03.009]
The immune reconstitution after an allogeneic stem cell transplant correlates with the risk of graft-versus-host disease and cytomegalovirus infection
GENTILE, Giuseppe;GUARINI, Anna;FOA, Roberto
2011
Abstract
Aim of the study was to correlate the clinical outcome of eighteen patients who have undergone an allogeneic stem cell transplant (SCT) with the concentration in the peripheral blood (PB) of lymphocyte subpopulations evaluated at 1 year from transplant. The occurrence of acute GVHD and CMV infection correlated with the concentration of Tregs in the PB; CMV infection also correlated with the content of NK cells. The obtained results document that the concentration of Tregs in the PB after an allogeneic SCT may protect from GVHD and from CMV infection; the potential anti-viral role of NK cells is confirmed. © 2011 Elsevier Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
