Objective: The goal of this study was to define the long-term outcome of absence epilepsy presenting before the age of 3 years. Methods: We retrospectively studied the medical records of 40 children from eight neuropediatric centers in Italy with respect to the personal and family histories of epilepsy or febrile seizures, time of follow-up, cognitive functions, treatment, and outcome. Results: Forty patients were enrolled in this study. They all fulfilled the criteria for absence epilepsy with 3-Hz spike-wave complexes on the EEG, normal neurological examination, and no other seizures types. Seizure onset occurred between 24.1 and 36.0 months. There was a family history of epilepsy in 28%, and of febrile seizures in 13%. Thirty-three patients were treated with valproic acid (VPA), mostly used in monotherapy (26 patients) or in association with ethosuximide. At final follow-up, 33 patients were seizure free and 29 had normal EEGs. Thirty-four patients had a normal intelligence quotient (IQ), whereas 6 had a decreased IQ mainly associated with poor control of seizures. Conclusion: In our series, absence seizures presenting before the age of 3 appeared to have quite a good long-term clinical prognosis; the neuropsychological outcome was comparable to that of childhood epilepsy presenting after 3 years of age.

Long term outcome in children affected by absence epilepsy with onset before the age of three years / Alberto, Verrotti; Cristina, Olivieri; Sergio, Agostinelli; Giangennaro, Coppola; Parisi, Pasquale; Salvatore, Grosso; Spalice, Alberto; Nelia, Zamponi; Emilio, Franzoni; Iannetti, Paola; Francesco, Chiarelli; Paolo, Curatolo. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - STAMPA. - 20:2(2011), pp. 366-369. [10.1016/j.yebeh.2010.12.015]

Long term outcome in children affected by absence epilepsy with onset before the age of three years

PARISI, Pasquale
Supervision
;
Alberto Spalice;Paola Iannetti;
2011

Abstract

Objective: The goal of this study was to define the long-term outcome of absence epilepsy presenting before the age of 3 years. Methods: We retrospectively studied the medical records of 40 children from eight neuropediatric centers in Italy with respect to the personal and family histories of epilepsy or febrile seizures, time of follow-up, cognitive functions, treatment, and outcome. Results: Forty patients were enrolled in this study. They all fulfilled the criteria for absence epilepsy with 3-Hz spike-wave complexes on the EEG, normal neurological examination, and no other seizures types. Seizure onset occurred between 24.1 and 36.0 months. There was a family history of epilepsy in 28%, and of febrile seizures in 13%. Thirty-three patients were treated with valproic acid (VPA), mostly used in monotherapy (26 patients) or in association with ethosuximide. At final follow-up, 33 patients were seizure free and 29 had normal EEGs. Thirty-four patients had a normal intelligence quotient (IQ), whereas 6 had a decreased IQ mainly associated with poor control of seizures. Conclusion: In our series, absence seizures presenting before the age of 3 appeared to have quite a good long-term clinical prognosis; the neuropsychological outcome was comparable to that of childhood epilepsy presenting after 3 years of age.
2011
early-onset absence epilepsy; ethosuximide; outcome; valproic acid; long-term outcome
01 Pubblicazione su rivista::01a Articolo in rivista
Long term outcome in children affected by absence epilepsy with onset before the age of three years / Alberto, Verrotti; Cristina, Olivieri; Sergio, Agostinelli; Giangennaro, Coppola; Parisi, Pasquale; Salvatore, Grosso; Spalice, Alberto; Nelia, Zamponi; Emilio, Franzoni; Iannetti, Paola; Francesco, Chiarelli; Paolo, Curatolo. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - STAMPA. - 20:2(2011), pp. 366-369. [10.1016/j.yebeh.2010.12.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/354580
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