The long natural history of early stage mycosis fungoides (MF) makes its management a difficult problem. Skin lesions are sensitive to different therapies and a variety of treatment modalities have been used, such as topical nitrogen mustard, puvatherapy, UV-B, retinoids, radiation therapy, extracorporal photopheresis and systemic chemotherapy. For patients with refractory early stage MF, treatment selection is made by clinical parameters such as the age, sex and performance status of the patients, as well as the institutional expertise and the toxicity profiles of the different therapeutic approaches. We report radiation therapy in a relapsed/resistant stage IB patient with mycosis fungoides treated with local radiation therapy for symptomatic progression unresponsive to bexarotene therapy. Total skin electron beam therapy has been employed in early stage and for limited skin failure MF, while the role of local radiation therapy in MF is less defined. In our experience local radiotherapy has proved to be a very efficient, tolerable and cost effective approach in patients with MF unresponsive to systemic approaches.

Role of radiation therapy in mycosis fungoides refractory to systemic therapy / DE SANCTIS, Vitaliana; Persechino, Severino; A., Fanelli; M., Valeriani; S., Bracci; M., D'Arienzo; Monarca, Bruno; C., Caperchi; Raffa, Salvatore; MAURIZI ENRICI, Riccardo; R. M., Enrici. - In: EUROPEAN JOURNAL OF DERMATOLOGY. - ISSN 1167-1122. - 21:2(2011), pp. 213-217. [10.1684/ejd.2010.1224]

Role of radiation therapy in mycosis fungoides refractory to systemic therapy

DE SANCTIS, Vitaliana;PERSECHINO, Severino;MONARCA, Bruno;RAFFA, SALVATORE;MAURIZI ENRICI, Riccardo;
2011

Abstract

The long natural history of early stage mycosis fungoides (MF) makes its management a difficult problem. Skin lesions are sensitive to different therapies and a variety of treatment modalities have been used, such as topical nitrogen mustard, puvatherapy, UV-B, retinoids, radiation therapy, extracorporal photopheresis and systemic chemotherapy. For patients with refractory early stage MF, treatment selection is made by clinical parameters such as the age, sex and performance status of the patients, as well as the institutional expertise and the toxicity profiles of the different therapeutic approaches. We report radiation therapy in a relapsed/resistant stage IB patient with mycosis fungoides treated with local radiation therapy for symptomatic progression unresponsive to bexarotene therapy. Total skin electron beam therapy has been employed in early stage and for limited skin failure MF, while the role of local radiation therapy in MF is less defined. In our experience local radiotherapy has proved to be a very efficient, tolerable and cost effective approach in patients with MF unresponsive to systemic approaches.
2011
local radiation therapy; mycosis fungoides; symptom control; progressive disease
01 Pubblicazione su rivista::01a Articolo in rivista
Role of radiation therapy in mycosis fungoides refractory to systemic therapy / DE SANCTIS, Vitaliana; Persechino, Severino; A., Fanelli; M., Valeriani; S., Bracci; M., D'Arienzo; Monarca, Bruno; C., Caperchi; Raffa, Salvatore; MAURIZI ENRICI, Riccardo; R. M., Enrici. - In: EUROPEAN JOURNAL OF DERMATOLOGY. - ISSN 1167-1122. - 21:2(2011), pp. 213-217. [10.1684/ejd.2010.1224]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/353815
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