In a series of 84 chronic lymphocytic leukemia (CLL) patients we sought to establish whether BAFF (B-cell activating factor of the TNF family) circulating levels correlated with clinical characteristics of disease. BAFF serum levels were significantly higher in 20 healthy controls (i.e., median 695 ng/mL, range 389-1040) in comparison to the whole population of CLL patients (median 376, range 93-8914:, P < 0.0001). After setting a cut-off at the median value observed in healthy controls (i.e., 695 ng/mL) we found that 6 out of 15 (40%) patients with familial CLL had increased BAFF levels while the same occurred only in 5 out of 64 (7.2%) patients with sporadic CLL (P = 0.0007). No significant difference in age (P = 0.82), sex (P = 0.97), Binet clinical stage (P = 0.20), incidence of autoimmune hemolytic anemia (AIHA) or immune thrombocytopenia (ITP) (P = 0.47), mutational status of IgVH (P = 1.00), CD38 (P = 0.34) and ZAP-70 expression (P = 0.16) could be detected between patients with sporadic and familial CLL, respectively. The only feature characterizing familial CLL patients was a higher serum BAFF level (sporadic CLL 336 ng/mL, range 93-925; familial CLL 601 ng/mL, range 138-8914; P = 0.002). Our data suggest that BAFF levels are elevated in patients with familial CLL. The small cohort of patients used implies that a larger study is needed to reinforce the observation.

Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia / Molica, S; Digiesi, G; Mauro, Francesca Romana; Mirabelli, R; Cutrona, G; Vitelli, G; Morabito, F; Iuliano, F; Foa, Roberto; Ferrarini, M.. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - 33 (1):(2009), pp. 162-165. [10.1016/j.leukres.2008.05.004]

Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia.

MAURO, Francesca Romana;FOA, Roberto;
2009

Abstract

In a series of 84 chronic lymphocytic leukemia (CLL) patients we sought to establish whether BAFF (B-cell activating factor of the TNF family) circulating levels correlated with clinical characteristics of disease. BAFF serum levels were significantly higher in 20 healthy controls (i.e., median 695 ng/mL, range 389-1040) in comparison to the whole population of CLL patients (median 376, range 93-8914:, P < 0.0001). After setting a cut-off at the median value observed in healthy controls (i.e., 695 ng/mL) we found that 6 out of 15 (40%) patients with familial CLL had increased BAFF levels while the same occurred only in 5 out of 64 (7.2%) patients with sporadic CLL (P = 0.0007). No significant difference in age (P = 0.82), sex (P = 0.97), Binet clinical stage (P = 0.20), incidence of autoimmune hemolytic anemia (AIHA) or immune thrombocytopenia (ITP) (P = 0.47), mutational status of IgVH (P = 1.00), CD38 (P = 0.34) and ZAP-70 expression (P = 0.16) could be detected between patients with sporadic and familial CLL, respectively. The only feature characterizing familial CLL patients was a higher serum BAFF level (sporadic CLL 336 ng/mL, range 93-925; familial CLL 601 ng/mL, range 138-8914; P = 0.002). Our data suggest that BAFF levels are elevated in patients with familial CLL. The small cohort of patients used implies that a larger study is needed to reinforce the observation.
2009
Familial CLL, BAFF, Prognosis
01 Pubblicazione su rivista::01a Articolo in rivista
Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia / Molica, S; Digiesi, G; Mauro, Francesca Romana; Mirabelli, R; Cutrona, G; Vitelli, G; Morabito, F; Iuliano, F; Foa, Roberto; Ferrarini, M.. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - 33 (1):(2009), pp. 162-165. [10.1016/j.leukres.2008.05.004]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/35232
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact