The synthesis of a new chiral agent, (R,R) (-)N, N'-trans-1, 2-dihexylcyclohexanediamine, for the chromatographic resolution of racemates is reported. Highly selective separations of D- and L-isomers of free and Dns-amino acids were accomplished on a reversed-phase column using in the mobile phase a Cu(II) complex of the above chiral selector. The procedure was extended to resolve diastereomeric derivatives, which were obtained by reaction of an optically active amine with o-phthaldeyde in the presence of N-acetyl-L-cysteine.
"Enantiomeric resolution of amino acids by reversed phase high performance liquid chromatography using a new mobile phase" / Federici, F.; Girelli, Anna Maria; Messina, Antonella; Nicoletti, I.; Sinibaldi, M.. - In: ANALYTICAL LETTERS. - ISSN 0003-2719. - STAMPA. - 23(1990), pp. 1565-1579. [10.1080/00032719008052508]
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Titolo: | "Enantiomeric resolution of amino acids by reversed phase high performance liquid chromatography using a new mobile phase" | |
Autori: | ||
Data di pubblicazione: | 1990 | |
Rivista: | ||
Citazione: | "Enantiomeric resolution of amino acids by reversed phase high performance liquid chromatography using a new mobile phase" / Federici, F.; Girelli, Anna Maria; Messina, Antonella; Nicoletti, I.; Sinibaldi, M.. - In: ANALYTICAL LETTERS. - ISSN 0003-2719. - STAMPA. - 23(1990), pp. 1565-1579. [10.1080/00032719008052508] | |
Handle: | http://hdl.handle.net/11573/34719 | |
Appartiene alla tipologia: | 01a Articolo in rivista |