Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-dependent growth inhibition, probably mediated by molecules present on adult hepatocyte membranes, provoked the decrease of amino acid uptake only in the adult cells. The results indicate that the different modulation of amino acid transport by cell growth is dependent on the age and the differentiation stage of hepatocytes
Amino acid uptake regulation by cell growth in cultured hepatocytes isolated from fetal and adult rats / Leoni, Silvia; Spagnuolo, S.; Massimi, M.; Terenzi, F.; Conti, Laura. - In: BIOSCIENCE REPORTS. - ISSN 0144-8463. - STAMPA. - 12:(1992), pp. 135-141. [10.1007/BF02351218]
Amino acid uptake regulation by cell growth in cultured hepatocytes isolated from fetal and adult rats
LEONI, Silvia;CONTI, Laura
1992
Abstract
Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-dependent growth inhibition, probably mediated by molecules present on adult hepatocyte membranes, provoked the decrease of amino acid uptake only in the adult cells. The results indicate that the different modulation of amino acid transport by cell growth is dependent on the age and the differentiation stage of hepatocytesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
