The objective of this study was to test the expression of the oct-4 and c-kit, both markers of stem cells, in the ectopic endometrial tissue of endometriotic lesions of women with severe endometriosis. Our findings show that ectopic epithelial cells express oct-4 and c-kit and this suggests that the ectopic endometrium in endometriosis has a stem cell origin and could explain the possible progression to ovarian cancer. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Expression of oct-4 and c-kit antigens in endometriosis / Pacchiarotti, Arianna; Caserta, Donatella; Marco, Sbracia; Moscarini, Massimo. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - STAMPA. - 95:3(2011), pp. 1171-1173. [10.1016/j.fertnstert.2010.10.029]