The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
"Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens / Olsovska, J.; Flieger, M.; Bachechi, F.; Messina, Antonella; Sinibaldi, M.. - In: CHIRALITY. - ISSN 0899-0042. - ELETTRONICO. - 11:(1999), pp. 291-300. [10.1002/(SICI)1520-636X(1999)11:4<291::AID-CHIR6>3.0.CO;2-4]
"Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens
MESSINA, Antonella;
1999
Abstract
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
