: Latitude-correlated polymorphisms can be due to either selection-driven evolution or gene flow. To discriminate between them, we propose an approach that studies subpopulations springing from a single population that have lived for generations at different latitudes and have had a low genetic admixture. These requirements are fulfilled to a large extent by Ashkenazi and Sephardi Jews. The original population lived at a latitude of 35 degrees N, where the Sephardis still live. The Ashkenazis, however, moved to a latitude of 50 degrees N, starting about 10 centuries ago. The present study examines 3 latitude-correlated polymorphisms: PGP, PGM1, and AHSG, We found that PGP*2 and AHSG*2 alleles most likely underwent selection-driven evolution, but that PGM1*ts allele was not similarly affected, Since temperature might have been considered a reasonable selective factor, we also studied a population living at >800 m above sea level from Aosta Valley (Italy).
Latitude-correlated genetic polymorphisms: selection or gene flow? / Ciminelli, Bm; Jodice, C; Scozzari, Rosaria; Corbo, Rm; Nahum, M; Pompei, F; Santachiara Benerecetti, Sa; Santolamazza, C; Morpurgo, G; Modiano, G.. - In: HUMAN BIOLOGY. - ISSN 0018-7143. - STAMPA. - 72(2000), pp. 557-571.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | Latitude-correlated genetic polymorphisms: selection or gene flow? | |
Autori: | ||
Data di pubblicazione: | 2000 | |
Rivista: | ||
Citazione: | Latitude-correlated genetic polymorphisms: selection or gene flow? / Ciminelli, Bm; Jodice, C; Scozzari, Rosaria; Corbo, Rm; Nahum, M; Pompei, F; Santachiara Benerecetti, Sa; Santolamazza, C; Morpurgo, G; Modiano, G.. - In: HUMAN BIOLOGY. - ISSN 0018-7143. - STAMPA. - 72(2000), pp. 557-571. | |
Handle: | http://hdl.handle.net/11573/32046 | |
Appartiene alla tipologia: | 01a Articolo in rivista |