Pregnancy in patients with myelodysplastic syndromes (MDS)

Volpicelli, P.; Latagliata, R.; Breccia, M.; Carmosino, I.; Stefanizzi, Caterina; Vozella, F.; Levi, A.; Natalino, F.; Alimena, Giuliana

doi:10.1016/j.leukres.2008.02.006

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We report 6 pregnancies in 5 females with low-risk myelodysplastic syndromes (MDS) (median age at diagnosis 28 years, range 26-29) observed in the last 15 years. In 2 cases pregnancy was concomitant to the diagnosis of MDS, in the remaining 4 cases the intervals from diagnosis were 2, 3, 4 and 9 years, respectively. One patient had a foetal growth retardation corrected with steroid treatment while the remaining 5 pregnancies were uneventful. After a median time from delivery of 104 months (range 18-187) none of the patients developed acute myeloid leukemia (AML) and all are alive in stable disease. In conclusion, selected females with low-risk MDS could not be discouraged to have full term pregnancies. © 2008 Elsevier Ltd. All rights reserved.

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Titolo:	Pregnancy in patients with myelodysplastic syndromes (MDS)
Autori:	P. Volpicelli R. Latagliata M. Breccia I. Carmosino STEFANIZZI, CATERINA F. Vozella A. Levi F. Natalino ALIMENA, Giuliana mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2008
Rivista:	LEUKEMIA RESEARCH
Abstract:	We report 6 pregnancies in 5 females with low-risk myelodysplastic syndromes (MDS) (median age at diagnosis 28 years, range 26-29) observed in the last 15 years. In 2 cases pregnancy was concomitant to the diagnosis of MDS, in the remaining 4 cases the intervals from diagnosis were 2, 3, 4 and 9 years, respectively. One patient had a foetal growth retardation corrected with steroid treatment while the remaining 5 pregnancies were uneventful. After a median time from delivery of 104 months (range 18-187) none of the patients developed acute myeloid leukemia (AML) and all are alive in stable disease. In conclusion, selected females with low-risk MDS could not be discouraged to have full term pregnancies. © 2008 Elsevier Ltd. All rights reserved.
Handle:	http://hdl.handle.net/11573/31979
Appare nella tipologia:	01a Articolo in rivista

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