CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to, positive or negative regulation of transcription, enhancer-blocking activities at developmentally regulated gene clusters and at imprinted loci, and X-chromosome inactivation. Here, we review recent data acquired with state-of-the-art technologies that illuminate possible mechanisms behind the diversity of CTCF functions. CTCF interacts with numerous protein partners, including cohesin, nucleophosmin, PARP1, Yy1 and RNA polymerase II. We propose that CTCF interacts with one or two different partners according to the biological context, applying the Roman principle of governance, 'divide and rule' (divide et impera).

CTCF and its protein partners: divide and rule? / J., Zlatanova; Caiafa, Paola. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 122:9(2009), pp. 1275-1284. [10.1242/jcs.039990]

CTCF and its protein partners: divide and rule?

CAIAFA, Paola
2009

Abstract

CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to, positive or negative regulation of transcription, enhancer-blocking activities at developmentally regulated gene clusters and at imprinted loci, and X-chromosome inactivation. Here, we review recent data acquired with state-of-the-art technologies that illuminate possible mechanisms behind the diversity of CTCF functions. CTCF interacts with numerous protein partners, including cohesin, nucleophosmin, PARP1, Yy1 and RNA polymerase II. We propose that CTCF interacts with one or two different partners according to the biological context, applying the Roman principle of governance, 'divide and rule' (divide et impera).
2009
chromatin organization; cohesin; ctcf; gene expression; nucleophosmin; parp1; rna polymerase ii; yy1
01 Pubblicazione su rivista::01a Articolo in rivista
CTCF and its protein partners: divide and rule? / J., Zlatanova; Caiafa, Paola. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 122:9(2009), pp. 1275-1284. [10.1242/jcs.039990]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/31574
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