Achievement of complete molecular responses in late chronic phase chronic myeloid leukaemia patients treated with pulsed imatinib while in minimal residual disease

Massimo, Breccia; Laura, Cannella; Caterina, Stefanizzi; Michelina, Santopietro; Rosa De Cuia,; Daniela, Diverio; Giuliana, Alimena

doi:10.1016/j.leukres.2008.10.024

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Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400 mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late CP, which were switched to imatinib while in CCR after interferon alpha (IFN alpha) and reached complete and stable molecular remission with intermittent drug administration at 400 mg/every 20 days/month. (C) 2008 Elsevier Ltd. All rights reserved.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/30630

Titolo:	Achievement of complete molecular responses in late chronic phase chronic myeloid leukaemia patients treated with pulsed imatinib while in minimal residual disease
Autori interni:	ALIMENA, Giuliana STEFANIZZI, CATERINA
Data di pubblicazione:	2009
Rivista:	LEUKEMIA RESEARCH
Abstract:	Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400 mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late CP, which were switched to imatinib while in CCR after interferon alpha (IFN alpha) and reached complete and stable molecular remission with intermittent drug administration at 400 mg/every 20 days/month. (C) 2008 Elsevier Ltd. All rights reserved.
Handle:	http://hdl.handle.net/11573/30630
Appare nelle tipologie:	01.a Pubblicazione su Rivista

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