X-ray diffraction (XRD) studies on the cationic liposomes (CL)-DNA complexes currently used in gene delivery have provided detailed structural informations on these compact, ordered self-assemblies sheding light on the poorly understood structure-activity relationship. Among these, the experiments carried out by using a synchrotron radiation source have showed an experimental resolution remarkably better than that achieved one by traditional in house apparatuses. Here we show a new experimental approach for the study of CL-DNA complexes, based on the employment of silicon wafers as substrates, which allows to obtain high-resolution structural informations by energy dispersive X-ray diffraction (EDXD).
A new approach for the study of cationic lipid-DNA complexes by EDXD / Caracciolo, Giulio; Caminiti, Ruggero; F., Natali; Congiu, Agostina. - In: CHEMICAL PHYSICS LETTERS. - ISSN 0009-2614. - STAMPA. - 366(2002), pp. 200-204.
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Titolo: | A new approach for the study of cationic lipid-DNA complexes by EDXD |
Autori: | |
Data di pubblicazione: | 2002 |
Rivista: | |
Citazione: | A new approach for the study of cationic lipid-DNA complexes by EDXD / Caracciolo, Giulio; Caminiti, Ruggero; F., Natali; Congiu, Agostina. - In: CHEMICAL PHYSICS LETTERS. - ISSN 0009-2614. - STAMPA. - 366(2002), pp. 200-204. |
Handle: | http://hdl.handle.net/11573/29952 |
Appartiene alla tipologia: | 01a Articolo in rivista |