The in vitro inhibitory activity of Lonidamine on the aerobic glycolysis of normal as well as leukemic lymphocytes has been investigated. The extent of the impairment of lactate production induced by Lonidamine on normal thymus (T)- and bone marrow (B)-derived lymphocytes was found to be dependent on their source of origin, i.e. residing or circulating pool. Among leukemia tested 'null' and B cell leukemias appeared the most affected metabolically by the compound. Administration in vivo of the drug to the patient with B cell chronic leukemia resulted in a decrease of lactate production by leukemic cells comparable to that induced in vitro. These metabolic changes were paralleled in normal, as well as in leukemic cells by ultrastructural lesions, mainly confined to the mitochondrial compartment.
Inhibition of aerobic glycolysis in normal and neoplastic lymphoid cells induced by lonidamine [1-(2,4-dichlorobenzyl)-I-H-indazol-3-carboxylic acid] / P. G., Natali; Salsano, Felice; M., Viora; A., Nista; W., Malorni; A., Marolla; C., De Martino. - In: ONCOLOGY. - ISSN 0030-2414. - STAMPA. - 41:SUPPL. 1(1984), pp. 7-14.
Inhibition of aerobic glycolysis in normal and neoplastic lymphoid cells induced by lonidamine [1-(2,4-dichlorobenzyl)-I-H-indazol-3-carboxylic acid]
SALSANO, Felice;
1984
Abstract
The in vitro inhibitory activity of Lonidamine on the aerobic glycolysis of normal as well as leukemic lymphocytes has been investigated. The extent of the impairment of lactate production induced by Lonidamine on normal thymus (T)- and bone marrow (B)-derived lymphocytes was found to be dependent on their source of origin, i.e. residing or circulating pool. Among leukemia tested 'null' and B cell leukemias appeared the most affected metabolically by the compound. Administration in vivo of the drug to the patient with B cell chronic leukemia resulted in a decrease of lactate production by leukemic cells comparable to that induced in vitro. These metabolic changes were paralleled in normal, as well as in leukemic cells by ultrastructural lesions, mainly confined to the mitochondrial compartment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.