The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.

The DNA Sequence-dependence of Nucleosome Positioning in vivo and in vitro / A., Travers; E., Hiriart; M., Churcher; M., Caserta; DI MAURO, Ernesto. - In: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. - ISSN 0739-1102. - STAMPA. - 27:6(2010), pp. 713-724. [10.1080/073911010010524942]

The DNA Sequence-dependence of Nucleosome Positioning in vivo and in vitro

DI MAURO, Ernesto
2010

Abstract

The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.
2010
angstrom resolution; chromatin-structure; cooperative binding; core particle; crystal-structure; high-resolution; histone octamer; micrococcal nuclease; saccharomyces-cerevisiae; yeast pho5 promoter
01 Pubblicazione su rivista::01a Articolo in rivista
The DNA Sequence-dependence of Nucleosome Positioning in vivo and in vitro / A., Travers; E., Hiriart; M., Churcher; M., Caserta; DI MAURO, Ernesto. - In: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. - ISSN 0739-1102. - STAMPA. - 27:6(2010), pp. 713-724. [10.1080/073911010010524942]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/28779
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