The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.
The DNA Sequence-dependence of Nucleosome Positioning in vivo and in vitro / A., Travers; E., Hiriart; M., Churcher; M., Caserta; DI MAURO, Ernesto. - In: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. - ISSN 0739-1102. - STAMPA. - 27:6(2010), pp. 713-724. [10.1080/073911010010524942]
The DNA Sequence-dependence of Nucleosome Positioning in vivo and in vitro
DI MAURO, Ernesto
2010
Abstract
The contribution of histone-DNA interactions to nucleosome positioning in vivo is currently a matter of debate. We argue here that certain nucleosome positions, often in promoter regions, in yeast may be, at least in part, specified by the DNA sequence. In contrast other positions may be poorly specified. Positioning thus has both statistical and DNA-determined components. We further argue that the relative affinity of the octamer for different DNA sequences can vary and therefore the interaction of histones with the DNA is a 'tunable' property.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.