Abstract: Background: Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%). Aim: To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication. Methods: A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or C-13 urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended. Results: All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects. Conclusions: The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation.
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|Titolo:||A new highly effective short-term therapy schedule for Helicobacter pylori eradication.|
|Data di pubblicazione:||2000|
|Appare nella tipologia:||01a Articolo in rivista|