Some coumarin 7-substituted cephalosporins and related sulfones were prepared and an antimicrobial assay was performed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) carried out on cephalosporins showed a potential activity of some of the synthesized compounds against Gram-positive microorganisms. The tests performed on the corresponding sulfones showed no significant activity, neither as antimicrobial agents nor as inhibitors of beta-lactamase. An association of sulfone 6a with ampicillin was observed to inhibit Gram-positive microorganisms with a lower MIC than for ampicillin alone. (C) 1998 Elsevier Science S.A. All rights reserved.
Synthesis and antimicrobial activity of coumarin 7-substituted cephalosporins and sulfones / Leonardo, Bonsignore; Filippo, Cottiglia; Elkhaili, H.; Françoise, Jehl; Lavagna, Silvio Massimo; Giuseppe, Loy; Manna, Fedele; Henry, Monteil; Davide, Pompei; Secci, Daniela. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 53:6(1998), pp. 425-430. [10.1016/s0014-827x(98)00047-0]
Synthesis and antimicrobial activity of coumarin 7-substituted cephalosporins and sulfones
LAVAGNA, Silvio Massimo;MANNA, Fedele;Daniela Secci
1998
Abstract
Some coumarin 7-substituted cephalosporins and related sulfones were prepared and an antimicrobial assay was performed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) carried out on cephalosporins showed a potential activity of some of the synthesized compounds against Gram-positive microorganisms. The tests performed on the corresponding sulfones showed no significant activity, neither as antimicrobial agents nor as inhibitors of beta-lactamase. An association of sulfone 6a with ampicillin was observed to inhibit Gram-positive microorganisms with a lower MIC than for ampicillin alone. (C) 1998 Elsevier Science S.A. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
