The aim of this article is to show the close relationship between DNA methylation and poly(ADP-ribosyl)ation which are two important nuclear enzymatic mechanisms. An open question is to explain how some CpG dinucleotides, in particular those present into CpG islands, can maintain their unmethylated state in spite of the presence of active DNA methyltransferase in chromatin. This paper illustrates some data indicating that H1 histone is a possible trans-acting factor involved in protecting genomic DNA from full methylation and proposes that the somatic variant H1e, in its poly(ADP-ribosyl)ated isoform, is the protein capable of undertaking this role.
Correlation between DNA methylation and poly(ADP-ribosyl)ation processes / Zardo, Giuseppe; Marenzi, S; Caiafa, Paola. - In: GENE THERAPY & MOLECULAR BIOLOGY. - ISSN 1529-9120. - 1:(1998), pp. 661-679.
Correlation between DNA methylation and poly(ADP-ribosyl)ation processes
ZARDO, GIUSEPPE;CAIAFA, Paola
1998
Abstract
The aim of this article is to show the close relationship between DNA methylation and poly(ADP-ribosyl)ation which are two important nuclear enzymatic mechanisms. An open question is to explain how some CpG dinucleotides, in particular those present into CpG islands, can maintain their unmethylated state in spite of the presence of active DNA methyltransferase in chromatin. This paper illustrates some data indicating that H1 histone is a possible trans-acting factor involved in protecting genomic DNA from full methylation and proposes that the somatic variant H1e, in its poly(ADP-ribosyl)ated isoform, is the protein capable of undertaking this role.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
