An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by CI, p115, is synthesized predominantly in cells of hematopoietic origin, It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions, Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells.

An X chromosome-linked gene encoding a protein with characteristic of rhoGAP predominantely expressed in hematopietic cells / Tribioli, C.; Droetto, S.; Bione, S.; Cesareni, G.; Torrisi, Maria Rosaria; Lotti, Lavinia Vittoria; Lanfrancone, L.; Toniolo, D.; Pelicci, P. G.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 23:(1996), pp. 695-699. [10.1073/pnas.93.2.695]

An X chromosome-linked gene encoding a protein with characteristic of rhoGAP predominantely expressed in hematopietic cells.

TORRISI, Maria Rosaria;LOTTI, Lavinia Vittoria;
1996

Abstract

An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by CI, p115, is synthesized predominantly in cells of hematopoietic origin, It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions, Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells.
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An X chromosome-linked gene encoding a protein with characteristic of rhoGAP predominantely expressed in hematopietic cells / Tribioli, C.; Droetto, S.; Bione, S.; Cesareni, G.; Torrisi, Maria Rosaria; Lotti, Lavinia Vittoria; Lanfrancone, L.; Toniolo, D.; Pelicci, P. G.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 23:(1996), pp. 695-699. [10.1073/pnas.93.2.695]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/256958
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