We give here evidence that Purkinje neurons (PNs) of mouse cerebellar slices studied with patch clamp technique combined with laser confocal microscopy, respond to human IL-8 and GROalpha by (i) a cytosolic Ca2+ transient compatible with inositol (1,4,5) trisphosphate (InsP3) formation; (ii) an enhancement of the neurotransmitter release; and (iii) an impairment of the long-term depression of synaptic strength (LTD). It was also found the expression of IL-8 receptor type 2 in PN and granule cells by immunofluorescence, immunoblotting and RT-PCR analysis. Considered together these findings suggest that IL-8 and GROalpha may play a neuromodulatory role on mouse cerebellum.
CXC chemokine interleukin-8 (IL-8) and growth-related gene product (GROalpha)modulate Purkinje neuron activity in mouse cerebellum / Giovannelli, A.; Limatola, Cristina; Ragozzino, Davide Antonio; Mileo, A. M.; Ruggieri, A.; Ciotti, M. T.; Mercanti, D.; Santoni, Angela; Eusebi, Fabrizio. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 92(1998), pp. 122-132. [10.1016/S0165-5728(98)00192-1]
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Titolo: | CXC chemokine interleukin-8 (IL-8) and growth-related gene product (GROalpha)modulate Purkinje neuron activity in mouse cerebellum | |
Autori: | ||
Data di pubblicazione: | 1998 | |
Rivista: | ||
Citazione: | CXC chemokine interleukin-8 (IL-8) and growth-related gene product (GROalpha)modulate Purkinje neuron activity in mouse cerebellum / Giovannelli, A.; Limatola, Cristina; Ragozzino, Davide Antonio; Mileo, A. M.; Ruggieri, A.; Ciotti, M. T.; Mercanti, D.; Santoni, Angela; Eusebi, Fabrizio. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 92(1998), pp. 122-132. [10.1016/S0165-5728(98)00192-1] | |
Handle: | http://hdl.handle.net/11573/256923 | |
Appartiene alla tipologia: | 01a Articolo in rivista |