We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing-remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progcsterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.
MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns / Pozzilli, Carlo; Falaschi, Paolo; C., Mainero; A., Martocchia; J., Faroni; D'Urso, Rosaria; Proietti, Antonella; Frontoni, Marco; M., Filippi. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 53:3(1999), pp. 622-624.
MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns
POZZILLI, Carlo;FALASCHI, Paolo;D'URSO, Rosaria;PROIETTI, Antonella;FRONTONI, Marco;
1999
Abstract
We investigated MRI activity in MS during the menstrual cycle in relation to physiologic sex hormone fluctuations. Eight women with relapsing-remitting MS were submitted to serial brain gadolinium-enhanced MRI examinations over a 3-month period in two alternate follicular and luteal phases of the menstrual cycle. The ratio of progcsterone/17-beta-estradiol during the luteal phase was significantly associated with both number (r = 0.6, p = 0.03) and volume (r = 0.7, p = 0.009) of enhancing lesions, providing support for a role of these hormones as immunomodulatory factors in MS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
