Antennapedia homeobox peptide has been reported to enhance neurite outgrowth and branching, Thus it is of interest to investigate whether antennapedia peptide is capable of modulating the expression of genes related to different events of neuronal development. In this paper we report the enhancement of a 68 KDa neurofilament subunit, choline acetyltransferase and acetylcholinesterase expression in spinal cord neurons, elicited by antennapedia peptide. Modulation of gene expression is different with respect to each gene product analyzed, suggesting a specific action of the peptide on diverse genes controlling different events of neuronal differentiation. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.
Activation of neurospecific gene expression by antennapedia homeobox peptide / Biagioni, Stefano; Laura, Ciuffini; DE JACO, Antonella; Anna Lidia, Vignoli; Tocco, Gabriella. - In: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. - ISSN 0736-5748. - 18:1(2000), pp. 93-99. [10.1016/s0736-5748(99)00077-5]
Activation of neurospecific gene expression by antennapedia homeobox peptide
BIAGIONI, Stefano;DE JACO, Antonella;TOCCO, Gabriella
2000
Abstract
Antennapedia homeobox peptide has been reported to enhance neurite outgrowth and branching, Thus it is of interest to investigate whether antennapedia peptide is capable of modulating the expression of genes related to different events of neuronal development. In this paper we report the enhancement of a 68 KDa neurofilament subunit, choline acetyltransferase and acetylcholinesterase expression in spinal cord neurons, elicited by antennapedia peptide. Modulation of gene expression is different with respect to each gene product analyzed, suggesting a specific action of the peptide on diverse genes controlling different events of neuronal differentiation. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
