Central anticholinergic syndrome is a rarely observed condition in children. The occurrence of this syndrome after ingestion of Solanum pseudocapsicum is infrequent because findings tend to be milder and localized to the gastrointestinal system, without central nervous system involvement. Most patients do not present with diagnostic problems because their relatives can usually report any ingestion of poisonous agents; however, when drug poisoning or plant ingestion is uncertain, a differential diagnosis with encephalitis must be considered. Physostigmine salicylate is the specific antidote because it crosses the blood-brain barrier because of its tertiary ammonium group. Neostigmine methylsulfate has a quaternary ammonium group, which prevents its penetration through the blood-brain barrier; hence its primary influence is believed to be due to its action on the peripheral nervous system. We describe a female with central anticholinergic syndrome caused by ingestion of Solanum pseudocapsicum. A slow intravenous infusion of neostigmine methylsulfate (0.03 mg/kg) immediately resolved the clinical picture. To our knowledge, this case is the first reported of central anticholinergic syndrome occurring after ingestion of Solanum pseudocapsicum in a child and the first report of a complete and rapid remission after intravenous neostigmine methylsulfate administration.
VIENE DESCRITTO UN CASO CLINICO IN ETA' EVOLUTIVA IN CUI SI SEGNALA LA INSORGENZA DI UNA SINDROME ANTICOLINERGICA CENTRALE PER INGESTIONE ACCIDENTALE DELLE FOGLIE DI UNA PIANTA (SOLANUM PSEUDOCAPSICUM) AVVENUTA NEL GIARDINO DEI NONNI CUI ERA IN CUSTODIA LA BAMBINA. SI SEGNALANO LE PECULIARITA' DEL QUADRO CLINICO E LA UTILIZZAZIONE CON EFFICACIA "ATIPICA" E INATTESA DELLA NEOSTIGMINA , DISCUTENDO LA ALTERATA BARRIERA EMATOENCEFALICA LEGATA AL MOMENTO INFIAMMATORIO.
A female with central anticholinergic syndrome responsive to neostigmine / Parisi, Pasquale; Francia, Ada. - In: PEDIATRIC NEUROLOGY. - ISSN 0887-8994. - STAMPA. - 23:2(2000), pp. 185-187.
|Titolo:||A female with central anticholinergic syndrome responsive to neostigmine|
|Data di pubblicazione:||2000|
|Citazione:||A female with central anticholinergic syndrome responsive to neostigmine / Parisi, Pasquale; Francia, Ada. - In: PEDIATRIC NEUROLOGY. - ISSN 0887-8994. - STAMPA. - 23:2(2000), pp. 185-187.|
|Appartiene alla tipologia:||01a Articolo in rivista|