Acute effects of aflatoxins (AF), and in particular cardiac actions, have not been examined as much as chronic toxicity. Thus, in the present study we evaluated the effects of specific AF on isolated guinea pig atria. Isoprenaline (ISO, 4 x 10(-9)), AFB(1) (3 x 10(-6) and 6 x 10(-5) M) and AFG(1) (3 x 10(-6) and 6 x 10(-6) M) contracted the isolated guinea pig atria, leaving the preparation hyperresponsive to ISO. These properties of AF are of interest as they could be responsible of certain cardiotoxic effects described in the literature. (C) 2000 Elsevier Science Ltd. All rights reserved.
Stimulation of guinea pig isolated atria by aflatoxins / H., Abdel Haq; Palmery, Maura; M. G., Leone; Saso, Luciano; Silvestrini, Bruno. - In: TOXICOLOGY IN VITRO. - ISSN 0887-2333. - STAMPA. - 14:3(2000), pp. 193-197. [10.1016/s0887-2333(00)00013-8]
Stimulation of guinea pig isolated atria by aflatoxins
PALMERY, Maura;SASO, Luciano;SILVESTRINI, Bruno
2000
Abstract
Acute effects of aflatoxins (AF), and in particular cardiac actions, have not been examined as much as chronic toxicity. Thus, in the present study we evaluated the effects of specific AF on isolated guinea pig atria. Isoprenaline (ISO, 4 x 10(-9)), AFB(1) (3 x 10(-6) and 6 x 10(-5) M) and AFG(1) (3 x 10(-6) and 6 x 10(-6) M) contracted the isolated guinea pig atria, leaving the preparation hyperresponsive to ISO. These properties of AF are of interest as they could be responsible of certain cardiotoxic effects described in the literature. (C) 2000 Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
