Cytokines and anticytokines are used increasingly in the treatment of immune, autoimmune, inflammatory, infectious, and malignant disorders. Commonly used treatments include the anti–tumor necrosis factor agents interferon alpha, interferon beta, interferon gamma, and interleukin 2. Several autoimmune phenomena have been reported in patients treated with these substances. This review summarizes the published data on the autoimmune manifestations associated with cytokine and anticytokine therapies, as well as describes possible mechanisms of these phenomena.
Autoimmune aspects of cytokine and anticytokine therapies / Irit, Krause; Valesini, Guido; Scrivo, Rossana; Yehuda, Shoenfeld. - In: THE AMERICAN JOURNAL OF MEDICINE. - ISSN 0002-9343. - STAMPA. - 115:5(2003), pp. 390-397. [10.1016/s0002-9343(03)00390-5]
Autoimmune aspects of cytokine and anticytokine therapies
VALESINI, Guido;SCRIVO, Rossana;
2003
Abstract
Cytokines and anticytokines are used increasingly in the treatment of immune, autoimmune, inflammatory, infectious, and malignant disorders. Commonly used treatments include the anti–tumor necrosis factor agents interferon alpha, interferon beta, interferon gamma, and interleukin 2. Several autoimmune phenomena have been reported in patients treated with these substances. This review summarizes the published data on the autoimmune manifestations associated with cytokine and anticytokine therapies, as well as describes possible mechanisms of these phenomena.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
