The aim of the study was to evaluate plasma adrenomedullin (AM) concentration in primary hyperparathyroidism (PHP) and its effect on the regulation of blood pressure. Forty-one patients with PHP (25 normotensive and 16 hypertensive), and 31 healthy subjects (HS) were included in the study. As expected the total and ionized calcium and i-PTH serum levels were significantly higher in patients with PHP than in HS (P < .001). No significant difference was found in calcium-phosphorus metabolism parameters between normotensive and hypertensive PHP patients. Serum i-PTH levels correlated positively with systolic blood pressure (SBP) (r = 0.510; P < .02), diastolic blood pressure (DBP) (r = 0.586; P < .01) and heart rate (HR) (r = 0.486; P < .043) only in hypertensive PHP patients. Overall, mean plasma AM concentrations were significantly higher in PHP patients (16.1 +/- 7.9 pg/mL) than in HS (11.3 +/- 4.8 pg/mL) (P < .003) and correlated with i-PTH (r = 0.430; P < .005). However, in hypertensive PHP patients plasma AM levels (22.5 +/- 4.7 pg/mL) were higher than in normotensive PHP patients (11.6 +/- 1.8 pg/mL) (P < .001) and correlated with DBP (r = 0.902, P < .0029). In HS no correlation was found between plasma AM values and biohumoral, hormonal, or hemodynamic parameters. In conclusion, we demonstrated that in patients with PHP, plasma AM concentrations are increased and correlate with i-PTH and blood pressure values. We suggest that increased AM levels could be a compensatory factor in the defence mechanism against further blood pressure elevation. Copyright 2003, Elsevier Science (USA). All rights reserved.

Adrenomedullin concentrations are elevated in plasma of patients with primary hyperparathyroidism / Letizia, Claudio; C., Caliumi; E., Delfini; M., Celi; S., Subioli; Diacinti, Daniele; Minisola, Salvatore; D'Erasmo, Emilio; G. F., Mazzuoli. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 52:2(2003), pp. 159-162. [10.1053/meta.2003.50034]

Adrenomedullin concentrations are elevated in plasma of patients with primary hyperparathyroidism

LETIZIA, Claudio;DIACINTI, Daniele;MINISOLA, Salvatore;D'ERASMO, Emilio;
2003

Abstract

The aim of the study was to evaluate plasma adrenomedullin (AM) concentration in primary hyperparathyroidism (PHP) and its effect on the regulation of blood pressure. Forty-one patients with PHP (25 normotensive and 16 hypertensive), and 31 healthy subjects (HS) were included in the study. As expected the total and ionized calcium and i-PTH serum levels were significantly higher in patients with PHP than in HS (P < .001). No significant difference was found in calcium-phosphorus metabolism parameters between normotensive and hypertensive PHP patients. Serum i-PTH levels correlated positively with systolic blood pressure (SBP) (r = 0.510; P < .02), diastolic blood pressure (DBP) (r = 0.586; P < .01) and heart rate (HR) (r = 0.486; P < .043) only in hypertensive PHP patients. Overall, mean plasma AM concentrations were significantly higher in PHP patients (16.1 +/- 7.9 pg/mL) than in HS (11.3 +/- 4.8 pg/mL) (P < .003) and correlated with i-PTH (r = 0.430; P < .005). However, in hypertensive PHP patients plasma AM levels (22.5 +/- 4.7 pg/mL) were higher than in normotensive PHP patients (11.6 +/- 1.8 pg/mL) (P < .001) and correlated with DBP (r = 0.902, P < .0029). In HS no correlation was found between plasma AM values and biohumoral, hormonal, or hemodynamic parameters. In conclusion, we demonstrated that in patients with PHP, plasma AM concentrations are increased and correlate with i-PTH and blood pressure values. We suggest that increased AM levels could be a compensatory factor in the defence mechanism against further blood pressure elevation. Copyright 2003, Elsevier Science (USA). All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/254848
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