Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena. The ubiquitous presence of PTGS in both the plant and animal kingdoms and the finding of common genetic mechanisms suggest that PTGS is a universal gene-regulation system fundamental in biological processes such as protection against viruses and transposons.
Post-transcriptional gene silencing across kingdoms / Cogoni, Carlo; Macino, Giuseppe. - In: CURRENT OPINION IN GENETICS & DEVELOPMENT. - ISSN 0959-437X. - 10:6(2000), pp. 638-643. [10.1016/s0959-437x(00)00134-9]
Post-transcriptional gene silencing across kingdoms
COGONI, Carlo;MACINO, Giuseppe
2000
Abstract
Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena. The ubiquitous presence of PTGS in both the plant and animal kingdoms and the finding of common genetic mechanisms suggest that PTGS is a universal gene-regulation system fundamental in biological processes such as protection against viruses and transposons.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
