In this work, surface minimizing the risk of device-associated infections, through antibiotic adsorption on suitably modified biocompatible polymeric materials were developed. To improve the resistance of the device to microbial infections, a combination of two antibiotics, cefamandole nafate (CEF) and a rifampin (RIF), having different action mechanisms, were adsorbed on functionalized polyurethane films. Antibiotic release increased by adding, as pore formers, polyethylenglycol (PEG) of a different molecular weight.
Antimicrobial polyurethanes containing an association of antibiotics / Bellusci, Mariangela; Francolini, Iolanda; Piozzi, Antonella; Ruggeri, Valeria. - In: JOURNAL OF APPLIED BIOMATERIALS & BIOMECHANICS. - ISSN 1722-6899. - STAMPA. - 1(3):(2003), pp. 224-224. (Intervento presentato al convegno Società Italiana Biomateriali-Gruppo Interdivisionale di Biomateriali 2003 Italian National Congress tenutosi a Ischia nel 8-10 settembre) [10.5301/JABB.2008.3924].
Antimicrobial polyurethanes containing an association of antibiotics
BELLUSCI, Mariangela;FRANCOLINI, IOLANDA;PIOZZI, Antonella;RUGGERI, VALERIA
2003
Abstract
In this work, surface minimizing the risk of device-associated infections, through antibiotic adsorption on suitably modified biocompatible polymeric materials were developed. To improve the resistance of the device to microbial infections, a combination of two antibiotics, cefamandole nafate (CEF) and a rifampin (RIF), having different action mechanisms, were adsorbed on functionalized polyurethane films. Antibiotic release increased by adding, as pore formers, polyethylenglycol (PEG) of a different molecular weight.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
