The analgesic properties of Epilobium angustifolium (Ea), a plant containing flavonoids with anti-inflammatory activity, have not been sufficiently studied so far. Thus, we decided to evaluate, by the classical hot plate test and the writhing test, the analgesic effect of a dry extract of Ea obtained by evaporating a commercially available mother tincture. In the former assay, the effect of Ea (380 mg/kg) was slightly lower than that of morphine (10 mg/kg s.c.). In the writhing test, which is more sensitive for non-steroidal analgesics, the effect of Ea was already significant (P0.05) at 95 mg/kg while at doses 190 mg/kg, its activity was similar to that of lysine acetylsalicylate (300 mg/kg). The LD50 of this dry extract of Ea was 1.40.1 g/kg. Further studies are necessary for the identification of the active principles and the elucidation of their mechanism of action.

Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test / Tita, Beatrice; Hanin Abdel, Haq; Vitalone, Annabella; Mazzanti, Gabriela; Saso, Luciano. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 56:5-7(2001), pp. 341-343. (Intervento presentato al convegno Workshop of the Italian-Society-of-Pharmacognosy (SIPHAR) tenutosi a ASSISI, ITALY nel SEP 19, 2000) [10.1016/s0014-827x(01)01046-1].

Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test

TITA, Beatrice;VITALONE, Annabella;MAZZANTI, Gabriela;SASO, Luciano
2001

Abstract

The analgesic properties of Epilobium angustifolium (Ea), a plant containing flavonoids with anti-inflammatory activity, have not been sufficiently studied so far. Thus, we decided to evaluate, by the classical hot plate test and the writhing test, the analgesic effect of a dry extract of Ea obtained by evaporating a commercially available mother tincture. In the former assay, the effect of Ea (380 mg/kg) was slightly lower than that of morphine (10 mg/kg s.c.). In the writhing test, which is more sensitive for non-steroidal analgesics, the effect of Ea was already significant (P0.05) at 95 mg/kg while at doses 190 mg/kg, its activity was similar to that of lysine acetylsalicylate (300 mg/kg). The LD50 of this dry extract of Ea was 1.40.1 g/kg. Further studies are necessary for the identification of the active principles and the elucidation of their mechanism of action.
2001
analgesic activity; epilobium angustifolium; flavonoids; hot plate; writhing test
01 Pubblicazione su rivista::01a Articolo in rivista
Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test / Tita, Beatrice; Hanin Abdel, Haq; Vitalone, Annabella; Mazzanti, Gabriela; Saso, Luciano. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 56:5-7(2001), pp. 341-343. (Intervento presentato al convegno Workshop of the Italian-Society-of-Pharmacognosy (SIPHAR) tenutosi a ASSISI, ITALY nel SEP 19, 2000) [10.1016/s0014-827x(01)01046-1].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/254416
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